12 Result(s)
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Jonathan A McCullers
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Article
Open AccessVirulent PB1-F2 residues: effects on fitness of H1N1 influenza A virus in mice and changes during evolution of human influenza A viruses
Specific residues of influenza A virus (IAV) PB1-F2 proteins may enhance inflammation or cytotoxicity. In a series of studies, we evaluated the function of these virulence-associated residues in the context of...
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Article
Open AccessGlycosylation changes in the globular head of H3N2 influenza hemagglutinin modulate receptor binding without affecting virus virulence
Since the emergence of human H3N2 influenza A viruses in the pandemic of 1968, these viruses have become established as strains of moderate severity. A decline in virulence has been accompanied by glycan accum...
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Article
Open AccessAssociation of sputum microbiota profiles with severity of community-acquired pneumonia in children
Competitive interactions among bacteria in the respiratory tract microbiota influence which species can colonize and potentially contribute to pathogenesis of community-acquired pneumonia (CAP). However, under...
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Article
Open AccessViral suppressors of the RIG-I-mediated interferon response are pre-packaged in influenza virions
The type I interferon (IFN) response represents the first line of defence to invading pathogens. Internalized viral ribonucleoproteins (vRNPs) of negative-strand RNA viruses induce an early IFN response by int...
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Article
Helminth infections predispose mice to pneumococcal pneumonia but not to other pneumonic pathogens
Pneumonia is the leading killer of children worldwide. Here, we report that helminth-infected mice develop fatal pneumonia when challenged with Streptococcus pneumoniae. Mice were chronically infected with either...
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Article
The co-pathogenesis of influenza viruses with bacteria in the lung
Mortality from influenza viruses is strongly linked to secondary bacterial invaders. In the most extreme example, more than 95% of the 50 million or more death...
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Chapter
Secondary Bacterial Infections in Influenza Virus Infection Pathogenesis
is often complicated by bacterial pathogens that colonize the nasopharynx and invade the middle ear and/or lung epithelium. Incidence and pathogenicity of influenza-bacterial are multifactorial processes ...
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Chapter
Therapeutics Against Influenza
Despite 75 years of research into prevention and treatment of influenza, the viruses that cause this disease continue to rank as some of the most important pathogens afflicting humans today. Progress in develo...
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Article
Open AccessThe age distribution of mortality due to influenza: pandemic and peri-pandemic
Pandemic influenza is said to 'shift mortality' to younger age groups; but also to spare a subpopulation of the elderly population. Does one of these effects dominate? Might this have important ramifications?
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Article
Seroprevalence of seasonal and pandemic influenza A viruses in domestic cats
Infection of domestic cats with pandemic H1N1 influenza virus has recently been documented. We conducted a seroprevalence survey and found that 17 of 78 (21.8%) cats sampled during the 2009–2010 influenza seas...
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Article
Open AccessDoes Glycosylation as a modifier of Original Antigenic Sin explain the case age distribution and unusual toxicity in pandemic novel H1N1 influenza?
A pandemic novel H1N1 swine-origin influenza virus has emerged. Most recently the World Health Organization has announced that in a country-dependent fashion, up to 15% of cases may require hospitalization, of...
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Article
Wild-type and attenuated influenza virus infection of the neonatal rat brain
Although influenza virus infection of humans has been associated with a wide spectrum of clinical neurological syndromes, the pathogenesis of influenza virus associated central nervous system (CNS) disease in ...
