25 Result(s)

Article

Randomized controlled trial of enteral vitamin D supplementation (ViDES) in infants <28 weeks gestational age or <1000 g birth weight: study protocol

Vitamin D is necessary to develop healthy lungs and other organs early in life. Most infants born before 28 weeks’ gestation have low vitamin D levels at birth and a limited intake during the first month. Ente...

Mar Romero-Lopez, Jon E. Tyson, Mamta Naik, Claudia Pedroza, Lindsay F. Holzapfel… in Trials (2024)

Article

Use of term reference infants in assessing the developmental outcome of extremely preterm infants: lessons learned in a multicenter study

Extremely preterm (EP) impairment rates are likely underestimated using the Bayley III norm-based thresholds scores and may be better assessed relative to concurrent healthy term reference (TR) infants born in...

Charles E. Green, Jon E. Tyson, Roy J. Heyne, Susan R. Hintz… in Journal of Perinatology (2023)

Article

Evaluation of negative binomial and zero-inflated negative binomial models for the analysis of zero-inflated count data: application to the telemedicine for children with medical complexity trial

Two characteristics of commonly used outcomes in medical research are zero inflation and non-negative integers; examples include the number of hospital admissions or emergency department visits, where the majo...

Kyung Hyun Lee, Claudia Pedroza, Elenir B. C. Avritscher, Ricardo A. Mosquera… in Trials (2023)

Article

Advantages of Bayesian monitoring methods in deciding whether and when to stop a clinical trial: an example of a neonatal cooling trial

Decisions to stop randomized trials are often based on traditional P value thresholds and are often unconvincing to clinicians. To familiarize clinical investigators with the application and advantages of Bayesia...

Claudia Pedroza, Jon E. Tyson, Abhik Das, Abbot Laptook, Edward F. Bell… in Trials (2016)

Article

Stop** guidelines for an effectiveness trial: what should the protocol specify?

Despite long-standing problems in decisions to stop clinical trials, stop** guidelines are often vague or unspecified in the trial protocol. Clear, well-conceived guidelines are especially important to assis...

Jon E. Tyson, Claudia Pedroza, Dennis Wallace, Carl D’Angio, Edward F. Bell… in Trials (2016)

Article

Comparative effectiveness of antihypertensive treatment for older children with primary hypertension: study protocol for a series of n-of-1 randomized trials

Children are increasingly being diagnosed with primary hypertension. The absence of comparative effectiveness research of antihypertensive medications in children has contributed to considerable differences in...

Joyce P. Samuel, Joshua A. Samuels, Lauren E. Brooks, Cynthia S. Bell… in Trials (2016)

Article

Apolipoprotein E genotype and outcome in infants with hypoxic–ischemic encephalopathy

Adults with the apolipoprotein E (APOE) gene alleles e4 and e2 are at high risk of poor neurological outcome after brain injury. The e4 allele has been associated with cerebral palsy (CP), and the e2 allele ha...

C. Michael Cotten, Ricki F. Goldstein, Scott A. McDonald… in Pediatric Research (2014)

Article

Effect of inborn vs. outborn delivery on neurodevelopmental outcomes in infants with hypoxic–ischemic encephalopathy: secondary analyses of the NICHD whole-body cooling trial

The effect of birth location on hypothermia-related outcomes has not been rigorously examined in the literature. In this study, we determined whether birth location had an impact on the benefits of whole-body ...

Girija Natarajan, Athina Pappas, Seetha Shankaran, Abbot R. Laptook… in Pediatric Research (2012)

Article

Cytokine profiles of preterm neonates with fungal and bacterial sepsis

Information on cytokine profiles in fungal sepsis (FS), an important cause of mortality in extremely low birthweight (ELBW) infants, is lacking. We hypothesized that cytokine profiles in the first 21 d of life...

Beena G. Sood, Seetha Shankaran, Robert L. Schelonka, Shampa Saha… in Pediatric Research (2012)

Article

The effects of aggressive vs. conservative phototherapy on the brainstem auditory evoked responses of extremely-low-birth-weight infants

This study was a two-center, stratified, parallel-group randomized trial comparing the effects of aggressive vs. conservative phototherapy on brainstem auditory evoked response (BAER) latencies in infants with...

Robert E. Lasky, Michael W. Church, Mark S. Orlando, Brenda H. Morris… in Pediatric Research (2012)

Article

Does Indomethacin Prophylaxis Benefit Extremely Low Birth Weight Infants? Results of a Placebo-Controlled Multicenter Trial

Jon E Tyson in Pediatric Research (2002)

Article

Vitamin (Vit.) A Supplementation to Increase Survival without Chronic Lung Disease (CLD) in Extremely Low Birth Weight (ELBW) Infants: A 14-Center Randomized Trial • 1161

Jon E Tyson, Richard A Ehrenkranz, Barbara J Stoll, Linda L Wright… in Pediatric Research (1998)

Article

Pattern of Improved Survival and Resource Utilization for Very Low Birth Weight (VLBW) Neonates (501-1500 gm) at Parkland Memorial Hospital Between 1977-1995 † 1275

Jeffrey R Kaiser, Kathleen A Kennedy, Jon E Tyson… in Pediatric Research (1998)

Article

Does Seeking Informed Consent for Single or Multiple Studies Compromise Maternal Satisfaction? An Observational Study of Mothers of Very-Low-Birthweight Infants ♦ 166

Callie G Rogers Emery, Jon E Tyson, Kathleen A Kennedy in Pediatric Research (1998)

Article

How Should Normal Values be Defined and Used for an Abnormal Population? Complexities Highlighted in a Multicenter Trial of Vitamin A Supplementation to Prevent Chronic Lung Disease (CLD) among Extremely Low Birth Weight(ELBW;≤1000 g) Infants 528

Kathleen A Kennedy, Jon E Tyson, Lisa Mele, Richard A Ehrenkranz… in Pediatric Research (1998)

Article

Training Pediatric Residents in Evidence-Based Ethics: An Exploratory Clinical Trial ♦ 161

Terri L Major-Kincade, Kathleen A Kennedy, Jon E Tyson in Pediatric Research (1998)

Article

Inter-center variation in concerns about ethical research design: Neonatal Network experience with Institutional Review Board (IRB) review.• 159

Ann R. Stark, Jon E. Tyson in Pediatric Research (1997)

Article

CENTER DIFFERENCES IN SURVIVAL WITHOUT CHRONIC LUNG DISEASE (CLD) IN VERY-LOW-BIRTH-WEIGHT (VLBW) INFANTS ARE NOT EXPLAINED BY POPULATION DIFFERENCES, OR THE PRESENCE AND EARLY MANAGEMENT OF RESPIRATORY DISTRESS SYNDROME (RDS) • 1524

Kathleen A Kennedy, Joel Verter, Jon E Tyson, David K Stevenson… in Pediatric Research (1997)

Article

OPTING-IN VS. OPTING-OUT: AN EXPLORATORY TRIAL OF TRADITIONAL AND MODIFIED INFORMED CONSENT FOR STUDIES WITH MINIMAL OR REDUCED RISK.• 236

Callie G Rogers, Jon E Tyson, R. Sue Broyles in Pediatric Research (1996)