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Article
Open AccessEnhancing NSCLC recurrence prediction with PET/CT habitat imaging, ctDNA, and integrative radiogenomics-blood insights
While we recognize the prognostic importance of clinicopathological measures and circulating tumor DNA (ctDNA), the independent contribution of quantitative image markers to prognosis in non-small cell lung ca...
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Article
Open AccessPredictive performance of different NTCP techniques for radiation-induced esophagitis in NSCLC patients receiving proton radiotherapy
This study aimed to compare the predictive performance of different modeling methods in develo** normal tissue complication probability (NTCP) models for predicting radiation-induced esophagitis (RE) in non–...
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Article
Open AccessAn algorithm for thoracic re-irradiation using biologically effective dose: a common language on how to treat in a “no-treat zone”
Re-irradiation (re-RT) is a technically challenging task for which few standardized approaches exist. This is in part due to the lack of a common platform to assess dose tolerance in relation to toxicity in th...
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Article
Effects of glutamine for prevention of radiation-induced esophagitis: a double-blind placebo-controlled trial
Purpose Acute radiation-induced esophagitis (ARIE) leads to treatment delays, decreased quality of life (QOL), and secondary adverse events such as weight loss. Grade 3 ARIE occurs in 15%–30% of patients undergoi...
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Article
Open AccessBevacizumab treatment for radiation brain necrosis: mechanism, efficacy and issues
Vascular damage is followed by vascular endothelial growth factor (VEGF) expression at high levels, which is an important mechanism forradiation brain necrosis development. Bevacizumab alleviates brain edema s...
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Article
Time to abandon single-site irradiation for inducing abscopal effects
Considerable interest is being directed toward combining immune-checkpoint inhibition (ICI) with radiotherapy to improve response rates to ICI, which have been disappointingly low at around 15–30% among patien...
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Article
Open AccessA systematic review of the cost and cost-effectiveness studies of immune checkpoint inhibitors
Escalating healthcare costs are necessitating the practice of value-based oncology. It is crucial to critically evaluate the economic impact of influential but expensive therapies such as immune checkpoint inh...
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Article
Open AccessDevelopment of an Immune-Pathology Informed Radiomics Model for Non-Small Cell Lung Cancer
With increasing use of immunotherapy agents, pretreatment strategies for identifying responders and non-responders is useful for appropriate treatment assignment. We hypothesize that the local immune micro-env...
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Article
Prognostic significance of nuclear or cytoplasmic nucleolin expression in human non-small cell lung cancer and its relationship with DNA-PKcs
This study investigated the expression of nucleolin in tissue samples in patients with non-small cell lung cancer (NSCLC). Nucleolin was studied to determine whether it has a prognostic value and if its levels...
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Article
Immunotherapy and stereotactic ablative radiotherapy (ISABR): a curative approach?
Substantial interest exists in the effects of immunotherapy; however, radiation therapy also has the potential to stimulate an antitumour immune response. In this Perspectives, the authors describe the rationa...
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Article
Open AccessA study on the evaluation method and recent clinical efficacy of bevacizumab on the treatment of radiation cerebral necrosis
In order to investigate the efficacy of bevacizumab on the treatment of radiation cerebral necrosis, patients who were diagnosed with radiation cerebral necrosis by imaging after stereotactic radiotherapy were...
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Article
Radiation with immunotherapy: an emerging combination for cancer treatment
Ionizing radiation (RT) delivered to solid tumors is well known to induce immunological changes within the local tumor microenvironment as well as elicit systemic responses that promote antitumor immunity. The...
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Article
Open AccessAssessing the robustness of passive scattering proton therapy with regard to local recurrence in stage III non-small cell lung cancer: a secondary analysis of a phase II trial
We assessed the robustness of passive scattering proton therapy (PSPT) plans for patients in a phase II trial of PSPT for stage III non-small cell lung cancer (NSCLC) by using the worst-case scenario method, a...
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Article
Open AccessImproved longitudinal length accuracy of gross tumor volume delineation with diffusion weighted magnetic resonance imaging for esophageal squamous cell carcinoma
To analyze the longitudinal length accuracy of gross tumor volume (GTV) delineation with diffusion weighted magnetic resonance imaging for esophageal squamous cell carcinoma (SCC).
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Article
Open AccessClinical outcome and predictors of survival and pneumonitis after stereotactic ablative radiotherapy for stage I non-small cell lung cancer
Stereotactic ablative radiotherapy (SABR) can achieve excellent local control rates in early-stage non-small cell lung cancer (NSCLC) and has emerged as a standard treatment option for patients who cannot unde...
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Article
Open AccessFDG uptake correlates with recurrence and survival after treatment of unresectable stage III non-small cell lung cancer with high-dose proton therapy and chemotherapy
We studied whether maximum standardized uptake values (SUV) from [18 F] PET/CT predict clinical outcome after concurrent proton/chemotherapy for stage III non-small cell lung cancer (NSCLC).
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Article
The expression of HIF-1α in primary hepatocellular carcinoma and its correlation with radiotherapy response and clinical outcome
The purpose of this study was to evaluate the relationship between hypoxia-inducible factor-1α (HIF-1α) protein expression in hepatocellular carcinoma (HCC), and responses of abdominal metastatic lymph nodes (...
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Primary Lung Cancer
Stereotactic ablative radiotherapy (SABR), also called stereotactic body radiation therapy (SBRT), has emerged as a promising treatment for early stage non-small cell lung cancer (NSCLC), particularly for pati...
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Chapter
Cancer of the Lung
Lung cancer is the leading cause of cancer death worldwide. Radiation therapy plays a crucial role in the management of lung cancer. However, conventional radiotherapy using two-dimensional radiotherapy to 60–...
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Chapter
Lung Cancer
Lung cancer is the most common cancer worldwide and accounts for the most cancer-related deaths.
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