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Article
Protocol-in-a-Day Workshop: Expediting IRB Approval for Junior and Senior Faculty
Delays in research protocol development may be a single factor that hinders the career progression of academic faculty. Structured educational guidance during this phase proves crucial in mitigating setbacks i...
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Radioprotectors in the Management of Lung Cancer
Radiation therapy has become increasingly important in the management of lung cancer at all stages. However, radiotherapy, given alone or with concurrent chemo- and immunotherapy, can have severe adverse effec...
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Article
Open AccessPredictive performance of different NTCP techniques for radiation-induced esophagitis in NSCLC patients receiving proton radiotherapy
This study aimed to compare the predictive performance of different modeling methods in develo** normal tissue complication probability (NTCP) models for predicting radiation-induced esophagitis (RE) in non–...
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Article
Radiation-Induced Cardiovascular Disease: Mechanisms, Prevention, and Treatment
Despite the advancements of modern radiotherapy, radiation-induced cardiovascular disease (RICVD) remains a common cause of morbidity and mortality among cancer survivors.
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Lung Cancer
Modern radiotherapy for NSCLC and SCLC involves the synthesis of decades of research and experience that have determined the optimal methods for treatment delivery, planning, and reproducibility. Depending on ...
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The Role of Patient-Generated Data in Personalized Oncology Care and Research: Opportunities and Challenges for Real-World Implementation
People living with cancer and its associated treatment can experience important physical, psychological, and social burdens. Furthermore, these burdens compromise health-related quality of life (HRQoL) not onl...
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Article
Open AccessCancer associated macrophage-like cells and prognosis of esophageal cancer after chemoradiation therapy
Cancer Associated Macrophage-Like cells (CAMLs) are polynucleated circulating stromal cells found in the bloodstream of numerous solid-tumor malignancies. Variations within CAML size have been associated with ...
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Article
Open AccessAnatomic change over the course of treatment for non–small cell lung cancer patients and its impact on intensity-modulated radiation therapy and passive-scattering proton therapy deliveries
To quantify tumor anatomic change of non-small cell lung cancer (NSCLC) patients given passive-scattering proton therapy (PSPT) and intensity-modulated radiation therapy (IMRT) through 6–7 weeks of treatment, ...
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Article
The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression
Ferroptosis, a form of regulated cell death caused by lipid peroxidation, was recently identified as a natural tumor suppression mechanism. Here, we show that ionizing radiation (IR) induces ferroptosis in can...
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Article
Circulating tumor DNA dynamics predict benefit from consolidation immunotherapy in locally advanced non-small-cell lung cancer
Circulating tumor DNA (ctDNA) molecular residual disease (MRD) following curative-intent treatment strongly predicts recurrence in multiple tumor types, but whether further treatment can improve outcomes in pa...
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Open AccessAuthor Correction: Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer
The original version of this Article contained an error in Fig. 2, in which the left y-axis labels ‘tDNA’ and ‘ctDNA’ were inadvertently inverted. This has been corrected in the PDF and HTML versions of the Artic...
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Open AccessCirculating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer
Subclonal architecture and genomic evolution of small-cell lung cancer (SCLC) under treatment has not been well studied primarily due to lack of tumor specimens, particularly longitudinal samples acquired duri...
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Article
Patient-reported lung symptoms as an early signal of impending radiation pneumonitis in patients with non-small cell lung cancer treated with chemoradiation: an observational study
Clinician ratings of concurrent chemoradiation (CRT)-induced radiation pneumonitis (RP) in patients with non-small cell lung cancer (NSCLC) are based on both imaging and patient-reported lung symptoms. We comp...
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Open AccessA research protocol for a pilot randomized controlled trial designed to examine the feasibility of a couple-based mind-body intervention for patients with metastatic lung cancer and their partners
Given the generally incurable nature of metastatic non-small cell lung cancer (mNSCLC), patients and their romantic partners are at risk for existential/spiritual distress. Although a handful of dyadic psychos...
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Article
Open AccessDosimetric comparison of the helical tomotherapy, volumetric-modulated arc therapy and fixed-field intensity-modulated radiotherapy for stage IIB-IIIB non-small cell lung cancer
The study aimed to compare the dosimetric parameters to target dose coverage and the critical structures in the treatment planning of helical tomotherapy (TOMO), volumetric-modulated arc therapy (VMAT), and fi...
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Open AccessA Novel Methodology using CT Imaging Biomarkers to Quantify Radiation Sensitivity in the Esophagus with Application to Clinical Trials
Personalized cancer therapy seeks to tailor treatment to an individual patient’s biology. Therefore, a means to characterize radiosensitivity is necessary. In this study, we investigated radiosensitivity in th...
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Depressive symptoms and positive affect in Chinese and United States breast cancer survivors: a cross-cultural comparison
Research in the area of cultural response pattern on questionnaires in the oncological setting and direct cross-cultural comparisons are lacking. This study examined response pattern in the reporting of depres...
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Article
Patterns of metastatic progression after definitive radiation therapy for early-stage and locally advanced non-small cell lung cancer
Current preclinical models of metastatic disease (particularly oligometastases) suggest that metastases appear in a hierarchical order. We attempted to identify systematic patterns of metastasis in non-small c...
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Article
Open AccessDelta-radiomics features for the prediction of patient outcomes in non–small cell lung cancer
Radiomics is the use of quantitative imaging features extracted from medical images to characterize tumor pathology or heterogeneity. Features measured at pretreatment have successfully predicted patient outco...
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Article
Differences in quality of life between American and Chinese breast cancer survivors
It has been speculated that cancer survivors in Asia may have lower quality of life (QOL) compared with their Western counterparts. However, no studies have made international comparisons in QOL using a compre...
