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Article
Open AccessInfluence of a chronic beta-blocker therapy on perioperative opioid consumption – a post hoc secondary analysis
Beta-blocker (BB) therapy plays a central role in the treatment of cardiovascular diseases. An increasing number of patients with cardiovascular diseases undergoe noncardiac surgery, where opioids are an integ...
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Article
Open AccessA brief questionnaire for measuring alarm fatigue in nurses and physicians in intensive care units
When exposed to hundreds of medical device alarms per day, intensive care unit (ICU) staff can develop “alarm fatigue” (i.e., desensitisation to alarms). However, no standardised way of quantifying alarm fatig...
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Article
Open AccessThe influence of patient characteristics on the alarm rate in intensive care units: a retrospective cohort study
Intensive care units (ICU) are often overflooded with alarms from monitoring devices which constitutes a hazard to both staff and patients. To date, the suggested solutions to excessive monitoring alarms have ...
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Article
Open AccessChange point detection for clustered expression data
To detect changes in biological processes, samples are often studied at several time points. We examined expression data measured at different developmental stages, or more broadly, historical data. Hence, the...
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Article
Open AccessA comparison of first-attempt cannulation success of peripheral venous catheter systems with and without wings and injection ports in surgical patients—a randomized trial
A peripheral venous catheter (PVC) is the most widely used device for obtaining vascular access, allowing the administration of fluids and medication. Up to 25% of adult patients, and 50% of pediatric patients...
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Article
Open AccessEpigenetic adaptations of the masticatory mucosa to periodontal inflammation
In mucosal barrier interfaces, flexible responses of gene expression to long-term environmental changes allow adaptation and fine-tuning for the balance of host defense and uncontrolled not-resolving inflammat...
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Article
Open AccessAssociation between genetic variants of the cholinergic system and postoperative delirium and cognitive dysfunction in elderly patients
Postoperative delirium (POD) and postoperative cognitive dysfunction (POCD) are frequent and serious complications after surgery. We aim to investigate the association between genetic variants in cholinergic c...
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Article
Open AccessContribution of IQ in young adulthood to the associations of education and occupation with cognitive ability in older age
Studies suggest that a higher education and occupation are each associated with a higher late-life cognitive ability, but their inter-relationships in their association with cognitive ability and the contribut...
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Article
Open AccessEstimands in epigenome-wide association studies
In DNA methylation analyses like epigenome-wide association studies, effects in differentially methylated CpG sites are assessed. Two kinds of outcomes can be used for statistical analysis: Beta-values and M-valu...
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Article
Open AccessPreoperative Comparison of Three Anticholinergic Drug Scales in Older Adult Patients and Development of Postoperative Delirium: A Prospective Observational Study
Postoperative delirium (POD) is a frequent and serious complication after surgery. Evidence of a relationship between anticholinergic medication and the development of delirium is inconclusive, but studies on ...
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Chapter
Spielerisch Daten reinigen
Moderne algorithmische Verfahren können auf beliebige, große Datensätze angewendet werden. Es gibt hierzu viele Tutorien und auch Anwendungsbeispiele. In diesen werden häufig jedoch Datensätze verwendet, die b...
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Article
Open AccessA FDG-PET radiomics signature detects esophageal squamous cell carcinoma patients who do not benefit from chemoradiation
Detection of patients with esophageal squamous cell carcinoma (ESCC) who do not benefit from standard chemoradiation (CRT) is an important medical need. Radiomics using 18-fluorodeoxyglucose (FDG) positron emi...
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Article
Open AccessStability of neuropsychological test performance in older adults serving as normative controls for a study on postoperative cognitive dysfunction
Studies of postoperative cognitive dysfunction (POCD) rely on repeat neuropsychological testing. The stability of the applied instruments, which are affected by natural variability in performance and measureme...
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Article
Open AccessDetection of suspicious interactions of spiking covariates in methylation data
In methylation analyses like epigenome-wide association studies, a high amount of biomarkers is tested for an association between the measured continuous outcome and different covariates. In the case of a cont...
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Article
Open AccessEmergence delirium in children is not related to intraoperative burst suppression – prospective, observational electrography study
Emergence-delirium is the most frequent brain dysfunction in children recovering from general anaesthesia, though the pathophysiological background remains unclear. The presented study analysed an association ...
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Article
Open AccessA combined epigenome- and transcriptome-wide association study of the oral masticatory mucosa assigns CYP1B1 a central role for epithelial health in smokers
The oral mucosa has an important role in maintaining barrier integrity at the gateway to the gastrointestinal and respiratory tracts. Smoking is a strong environmental risk factor for the common oral inflammat...
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Article
Open AccessNovel canine circovirus strains from Thailand: Evidence for genetic recombination
Canine circoviruses (CanineCV’s), belonging to the genus Circovirus of the Circoviridae family, were detected by next generation sequencing in samples from Thai dogs with respiratory symptoms. Genetic characteriz...
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Article
Open AccessAutomated multigroup outlier identification in molecular high-throughput data using bagplots and gemplots
Analyses of molecular high-throughput data often lack in robustness, i.e. results are very sensitive to the addition or removal of a single observation. Therefore, the identification of extreme observations is...
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Article
Attitudes, practice, and experience of German dentists regarding repair restorations
The aim of the present study was to perform a representative survey among German dentists about attitudes, practice, and experience regarding single-tooth repair restorations.
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Interaktive Tools für die Lehre der Statistischen Bioinformatik
Seit dem Einzug der DNA-Microarrays und der Next-Generation-Sequencing-Technologie in die molekulare Forschung unterrichten Biometriker in zunehmendem Maße Methoden der sogenannten „Statistischen Bioinformatik...
