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Article
Phase Ib Single- and Multiple-Dose Pharmacokinetic Study of Oral NV-52 in Healthy Volunteers
Background and objective: NV-52 is a novel synthetic flavonoid thromboxane synthase (TXS) inhibitor that may be useful for the maintenance of remission in inflammatory bowel disease (IBD). This s...
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Article
Effect of Plasma Protein Binding on Kinetics of Capillary Uptake and Efflux
We examined the effect of plasma protein binding on the kinetics of organ accumulation and washout of drugs using the single-pass Kety–Renkin–Crone capillary model. An equation relating the accumulation and wa...