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Reference Work Entry In depth
CDK11
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Living Reference Work Entry In depth
CDK11
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Article
Cyclin-dependent kinases: a family portrait
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Article
Open AccessTwo Isoforms of the Human Cyclin C Gene are Expressed Differentially Suggesting that they May Have Distinct Functions
Cyclin C is a highly conserved protein that is involved in divergent cellular processes. The exact roles of its isoforms are presently not very well defined and it is possible that there is a functional diverg...
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Article
Potentiation of neuroblastoma metastasis by loss of caspase-8
Genetic alterations are common in aggressive neuroblastomas, the most common form of solid tumour in children. In particular the deletion or suppression of the apoptotic protease caspase 8 is common in maligna...
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Article
Reply to “Expression and methylation of CASP8 in neuroblastoma: Identification of a promoter region”
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Article
Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN
Important roles have been suggested for caspase-8, caspase-9 and Apaf-1 in controlling tumor development and their sensitivity to chemotherapeutic agents. Methylation and deletion of Apaf-1 and CASP8 results in t...
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Article
Aggressive childhood neuroblastomas do not express caspase-8: an important component of programmed cell death
Neuroblastomas that overexpress N-Myc due to amplification of the MYCN oncogene are aggressive tumors that become very resistant to treatment by chemotherapy and irradiation. to identify tumor suppressor genes in...
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Article
Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN
Caspase 8 is a cysteine protease regulated in both a death-receptor-dependent and -independent manner during apoptosis. Here, we report that the gene for caspase 8 is frequently inactivated in neuroblastoma, a...
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Article
SHORT COMMUNICATIONS. Map** of five members of the cyclin gene family on chicken chromosomes by FISH
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Article
Fas activates NF-κB and induces apoptosis in T-cell lines by signaling pathways distinct from those induced by TNF-α
The p55 tumor necrosis factor (TNF) receptor and the Fas (CD95/APO-1) receptor share an intracellular domain necessary to induce apoptosis, suggesting they utilize common signaling pathways. To define pathways...
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Chapter
The PITSLRE protein kinase family
A family of p34cdc2 related protein kinases, the PITSLRE kinases, is generated by alternative splicing and promoter utilization from three duplicated and tandemly linked genes on human chromosome 1p36.3, which is...
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Chapter
Cell Cycle-Related Protein Kinases and T Cell Death
Programmed cell death (PCD), or apoptosis, involves the activation of a specific suicide program within a cell. PCD is responsible for such diverse activities as the elimination of cells during normal embryolo...
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Article
Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma
p58cdc2L1, a protein kinase implicated in apoptotic signaling, is one of eight separate kinases encoded by three tandemly duplicated and linked genes, which we have termed PITSLRE A, B and C. One allele of this c...
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Article
Characterization of the avian T cell receptor