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  1. Article

    Open Access

    Patient-derived orthotopic xenografts of pediatric brain tumors: a St. Jude resource

    Pediatric brain tumors are the leading cause of cancer-related death in children. Patient-derived orthotopic xenografts (PDOX) of childhood brain tumors have recently emerged as a biologically faithful vehicl...

    Kyle S. Smith, Ke Xu, Kimberly S. Mercer, Frederick Boop… in Acta Neuropathologica (2020)

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    Article

    Caspase-9 and Apaf-1 are expressed and functionally active in human neuroblastoma tumor cell lines with 1p36 LOH and amplified MYCN

    Important roles have been suggested for caspase-8, caspase-9 and Apaf-1 in controlling tumor development and their sensitivity to chemotherapeutic agents. Methylation and deletion of Apaf-1 and CASP8 results in t...

    Tal Teitz, Tie Wei, Dong Liu, Virginia Valentine, Marcus Valentine, Jose Grenet… in Oncogene (2002)

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    Article

    Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN

    Caspase 8 is a cysteine protease regulated in both a death-receptor-dependent and -independent manner during apoptosis. Here, we report that the gene for caspase 8 is frequently inactivated in neuroblastoma, a...

    Tal Teitz, Tie Wei, Marcus B. Valentine, Elio F. Vanin, Jose Grenet… in Nature Medicine (2000)

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    Article

    Alterations in the PITSLRE protein kinase gene complex on chromosome 1p36 in childhood neuroblastoma

    p58cdc2L1, a protein kinase implicated in apoptotic signaling, is one of eight separate kinases encoded by three tandemly duplicated and linked genes, which we have termed PITSLRE A, B and C. One allele of this c...

    Jill M. Lahti, Marcus Valentine, Jialing **ang, Bart Jones, Joseph Amann… in Nature Genetics (1994)

  5. No Access

    Article

    β1–4-galactosyltransferase gene expression is regulated during entry into the cell cycle and during the cell cycle

    Mammalian glycosyltransferases have been implicated in a wide variety of functions besidesN-linked glycosylation, including developmental processes. For this reason, we studied the effects of cell cycle and entry...

    Lisa Pouncey, John Easton, Lucie S. Heath… in Somatic Cell and Molecular Genetics (1991)