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Article
Flowdashboard: authoring pandemic dashboards with a transparent flow model
Data dashboards with intuitive visualizations make information more accessible and provide a more in-depth explanation. They have emerged as a crucial tool for effectively communicating pandemic information to...
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Article
Open AccessThe role and controversy of pelvic lymph node dissection in prostate cancer treatment: a focused review
Pelvic lymph node dissection (PLND) is commonly performed alongside radical prostatectomy. Its primary objective is to determine the lymphatic staging of prostate tumors by removing lymph nodes involved in lym...
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Article
Open AccessDevelopment of a stemness-related prognostic index to provide therapeutic strategies for bladder cancer
Bladder cancer (BC) is a heterogeneous disease with varying clinical outcomes. Recent evidence suggests that cancer progression involves the acquisition of stem-like signatures, and assessing stemness indices ...
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Article
Open AccessLASS2 enhances chemosensitivity to cisplatin by inhibiting PP2A-mediated β-catenin dephosphorylation in a subset of stem-like bladder cancer cells
The benefits of first-line, cisplatin-based chemotherapy for muscle-invasive bladder cancer are limited due to intrinsic or acquired resistance to cisplatin. Increasing evidence has revealed the implication of...
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Article
Open AccessThe influence of preoperative urodynamic parameters on clinical results in patients with benign prostatic hyperplasia after transurethral resection of the prostate
To identify the urodynamic parameters affecting the clinical outcomes of transurethral resection of the prostate(TURP) surgery for patients with benign prostatic hyperplasia(BPH) by multifactor analysis and es...
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Article
Open AccessNuclear linear-chain structure arises in carbon-14
The shape and internal structure of an atomic nucleus can change significantly with increasing excitation energy, angular momentum, or isospin asymmetry. As an example of this structural evolution, linear-chai...
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Article
Open AccessSpecific subsets of urothelial bladder carcinoma infiltrating T cells associated with poor prognosis
Comprehensive investigation of tumor-infiltrating lymphocytes in cancer is crucial to explore the effective immunotherapies, but the composition of infiltrating T cells in urothelial bladder carcinoma (UBC) re...
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Article
Paeonol Inhibits Glioma Growth In Vivo and In Vitro by Inducing Apoptosis and Cell Cycle Arrest
Glioma is the most common primary brain tumors with diverse biological behavior. Paeonol, a phenolic component extracted from the root bark of Paeonia × suffruticosa Andrews, Paeoniaceae, has demonstrated cytotox...
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Article
Open AccessComprehensive analysis of scRNA-Seq and bulk RNA-Seq reveals dynamic changes in the tumor immune microenvironment of bladder cancer and establishes a prognostic model
The prognostic management of bladder cancer (BLCA) remains a great challenge for clinicians. Recently, bulk RNA-seq sequencing data have been used as a prognostic marker for many cancers but do not accurately ...
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Article
ELK1 suppresses SYTL1 expression by recruiting HDAC2 in bladder cancer progression
ETS transcription factor (ELK1) stimulates the expression of genes at the onset of the cell cycle and participates in early developmental programming. Here, we investigated whether alterations of ELK1 lead to ...
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Article
Verapamil inhibited the development of ureteral stricture by blocking CaMK II-mediated STAT3 and Smad3/JunD pathways
Ureteral stricture (US) is a fibrotic process that leads to urinary tract obstruction and even kidney damage, with the characteristic of reduced extracellular matrix (ECM) degradation and increased collagen sy...
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Article
Open AccessIdentification of a novel metabolism-related gene signature associated with the survival of bladder cancer
Bladder cancer (BC) is one of the most common malignancies and has a relatively poor outcome worldwide. In this study, we attempted to construct a novel metabolism-related gene (MRG) signature for predicting t...
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Open AccessEvaluation of the value of the VI-RADS scoring system in assessing muscle infiltration by bladder cancer
The Vesical Imaging-Reporting and Data System (VI-RADS) was created in 2018, and a 5-point VI-RADS scoring system was proposed to determine whether the muscularis of the bladder has been infiltrated by tumor t...
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Article
β-decay study of neutron-rich nucleus 34Al
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Article
MicroRNA-92 promotes invasion and chemoresistance by targeting GSK3β and activating Wnt signaling in bladder cancer cells
miR-92 has been reported to be upregulated in several human cancers. Until now, its expression pattern and biological roles in human bladder cancer still remains unexplored. The present study aims to clarify i...
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Article
Open AccessExome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese
Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-wide association study by genoty** 12,685 Chinese, using a custom Illumina HumanExome BeadChip, to identify...
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Article
miR-9 promotes cell proliferation and inhibits apoptosis by targeting LASS2 in bladder cancer
MicroRNA-9 upregulation was reported in several tumors. However, its function and mechanism in human bladder cancer remains obscure. The present study aims to identify the expression pattern, biological roles ...
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Article
Apoptin induces apoptosis in nude mice allograft model of human bladder cancer by altering multiple bladder tumor-associated gene expression profiles
Bladder cancer (BC) is one of the most common human malignancies that account for major death in the world. Apoptin that is derived from chicken anemia virus (CAV) has displayed tumor-specific cytotoxic activi...
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Article
Expression and prognostic significance of a new tumor metastasis suppressor gene LASS2 in human bladder carcinoma
The LASS2 gene has been identified as a new tumor metastasis suppressor gene and has been seen to correlate with the degree of invasion and recurrence in carcinomas of prostate, breast, liver, ovarian, and pan...
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Article
Experimental research into the two-proton emissions from 17,18Ne, 28P and 28,29S
Two-proton emissions from the excited states of 17,18Ne, 28P and 28,29S were investigated experimentally by the radioactive beams bombarding on the 197Au target via the Coulomb excitation. The complete-kinematics...
