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Article
Open AccessMachine learning and experiments identifies SPINK1 as a candidate diagnostic and prognostic biomarker for hepatocellular carcinoma
Machine learning techniques have been widely used in predicting disease prognosis, including cancer prognosis. One of the major challenges in cancer prognosis is to accurately classify cancer types and stages ...
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Article
Open AccessBiomineralized tetramethylpyrazine-loaded PCL/gelatin nanofibrous membrane promotes vascularization and bone regeneration of rat cranium defects
Conventional electrospinning produces nanofibers with smooth surfaces that limit biomineralization ability. To overcome this disadvantage, we fabricated a tetramethylpyrazine (TMP)-loaded matrix-mimicking biom...
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Article
Open AccessGWAS Combined with WGCNA of Transcriptome and Metabolome to Excavate Key Candidate Genes for Rice Anaerobic Germination
Direct seeding of rice is a lightweight and simple cultivation method, which can effectively promote rice production. Anaerobic germination tolerance is one of the main traits of rice adaptability to direct se...
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Article
Open AccessA new method for mutation inducing in rice by using DC electrophoresis bath and its mutagenic effects
Mutation breeding is a significant means of increasing breeding efficiency and accelerating breeding process. In present study, we explored a new method for mutations inducing in rice (Oryza sativa L.) by using d...
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Article
Open AccessPsoralea corylifolia L.: a comprehensive review of its botany, traditional uses, phytochemistry, pharmacology, toxicology, quality control and pharmacokinetics
Psoralea corylifolia L. (PCL), referred to as “Bu-gu-zhi” in Chinese, has great medicinal values since ancient times. PCL is the dried ripe fruit of Psoralea corylifolia L., which has been widely used in traditio...
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Open AccessTargeted Identification of Rice Grain-Associated Gene Allelic Variation Through Mutation Induction, Targeted Sequencing, and Whole Genome Sequencing Combined with a Mixed-Samples Strategy
The mining of new allelic variation and the induction of new genetic variability are the basis for improving breeding efficiency.
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Article
Open AccessCREB3L1 promotes tumor growth and metastasis of anaplastic thyroid carcinoma by remodeling the tumor microenvironment
Anaplastic thyroid carcinoma (ATC) is an extremely malignant type of endocrine cancer frequently accompanied by extrathyroidal extension or metastasis through mechanisms that remain elusive. We screened for th...
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Open AccessGender differences in psychiatric outpatients: a before and during COVID-19 pandemic study in general hospitals from China
Little is known about the gender characteristics and the Corona Virus Disease 2019 (COVID-19) impact on psychiatric department outpatients in general hospitals in China.
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Open AccessNovel computer-aided reconstruction of soft tissue defects following resection of oral and oropharyngeal squamous cell carcinoma
Reconstruction of soft tissue defects following surgical tumor resection is important for quality of life in cancer patients with oral and oropharyngeal squamous cell carcinoma (SCC). This study presents a nov...
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Open AccessProdrug polymeric micelles integrating cancer-associated fibroblasts deactivation and synergistic chemotherapy for gastric cancer
The prognosis of patients with advanced gastric cancer (GC) remains unsatisfactory owing to distant metastasis and resistance to concurrent systemic therapy. Cancer-associated fibroblasts (CAFs), as essential ...
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Article
Open AccessThe short-term and long-term outcomes of indocyanine green tracer-guided laparoscopic radical gastrectomy in patients with gastric cancer
The safety and efficacy of indocyanine green (ICG) imaging navigational laparoscopic gastrectomy remain controversial. This study is to evaluate the short-term and long-term outcomes of ICG-guided laparoscopic...
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Open AccessCharacteristics of Fertility Transition Response to the Cumulative Effective Low Temperature in a Two-Line Male Sterile Rice Cultivar
Photo-thermo-sensitive genic male sterile (PTGMS) rice (Oryza sativa L.) is usually considered two-line male sterile rice because of its dual-purpose in two-line hybrid rice system: under short days and low tempe...
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Open AccessDynamic genome-wide association analysis and identification of candidate genes involved in anaerobic germination tolerance in rice
In Asian rice production, an increasing number of countries now choose the direct seeding mode because of rising costs, labour shortages and water shortages. The ability of rice seeds to undergo anaerobic germ...
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Article
Open AccessImprovement of rice blast resistance by develo** monogenic lines, two-gene pyramids and three-gene pyramid through MAS
Rice blast caused by Magnaporthe oryzae (M. oryzae) is one of the most destructive diseases in rice production. Development of resistant varieties through pyramiding of resistant (R) genes is considered as an eff...
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Article
Open AccessMeta-analysis of studies comparing conservative treatment with antibiotics and appendectomy for acute appendicitis in the adult
Appendectomy is considered the first treatment choice for appendicitis. However, controversy exists since conservative therapy is associated with fewer complications than appendectomy for patients with acute a...
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Article
Open AccessDevelopment of a core SNP arrays based on the KASP method for molecular breeding of rice
The development and utilization of genetic markers play a pivotal role in marker-assisted breeding of rice cultivars during pyramiding of valuable genes. Among molecular markers, SNPs have become the most prom...
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Article
Open AccessIdentification of Magnaporthe oryzae-elicited rice novel miRNAs and their targets by miRNA and degradome sequencing
MicroRNAs (miRNAs) play an important role in plant growth, development and responses to stresses. Rice blast is one of the most devastating diseases in rice production. However, little is known regarding the effe...
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Article
Open AccessThe effect of Lasik surgery on myopic anisometropes’ sensory eye dominance
Lasik is a common surgery for treating anisometropia. In this study, we asked a specific question: what’s the effect of Lasik surgery on anisometropes’ sensory eye dominance ? Fifteen myop...
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Article
Open AccessEpithelium-specific Ets transcription factor-1 acts as a negative regulator of cyclooxygenase-2 in human rheumatoid arthritis synovial fibroblasts
Rheumatoid arthritis (RA) is characterized by excessive synovial inflammation. Cyclooxygenase-2 (COX-2) is an enzyme that catalyzes the conversion of arachidonic acid (AA) into prostaglandins. Epithelium-speci...
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Open AccessRisk factors for early postoperative cognitive dysfunction after non-coronary bypass surgery in Chinese population
The present study was performed to investigate the incidence of early postoperative cognitive dysfunction (POCD) after non-coronary bypass surgery and the potential risk factors in Chinese population.
