10 Result(s)
within
Ji-young Kim
Biomedicine
Oncology
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Article
Open AccessSuppression of TNBC metastasis by doxazosin, a novel dual inhibitor of c-MET/EGFR
Triple-negative breast cancer (TNBC) is characterized by aggressive growth and a high propensity for recurrence and metastasis. Simultaneous overexpression of c-MET and EGFR in TNBC is associated with worse cl...
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Article
Open AccessCorrection to: Inhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin
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Article
Open AccessSecondhand smoke exposure, diabetes, and high BMI are risk factors for uterine cervical cancer: a cross-sectional study from the Korea national health and nutrition examination survey (2010–2018)
Human papilloma virus infection and tobacco smoking are the major risk factors for cervical cancer. There are limited studies searching other risk factors for cervical cancer and the results are not consistent...
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Article
Open AccessInhibition of mTORC1 through ATF4-induced REDD1 and Sestrin2 expression by Metformin
Although the major anticancer effect of metformin involves AMPK-dependent or AMPK-independent mTORC1 inhibition, the mechanisms of action are still not fully understood.
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Article
Open AccessA novel HSP90 inhibitor targeting the C-terminal domain attenuates trastuzumab resistance in HER2-positive breast cancer
Trastuzumab resistance in HER2-positive breast cancer is associated with a poorer prognosis. HSP90 is thought to play a major role in such resistance, but N-terminal inhibitors of this target have had little s...
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Article
Open AccessThe JAK2/STAT3/CCND2 Axis promotes colorectal Cancer stem cell persistence and radioresistance
Radiotherapy (RT) is a highly effective multimodal nonsurgical treatment that is essential for patients with advanced colorectal cancer (CRC). Nevertheless, cell subpopulations displaying intrinsic radioresist...
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Article
Oncogenic role of SIRT1 associated with tumor invasion, lymph node metastasis, and poor disease-free survival in triple negative breast cancer
The aim of this study is to evaluate the biological role and clinical implications of silent mating type information regulation 2 homolog 1 (SIRT1) as a novel candidate for target therapy in triple negative br...
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Article
Growth-suppressive effect of suberoylanilide hydroxamic acid (SAHA) on human oral cancer cells
The histone deacetylase (HDAC) inhibitor suberoylanilide hydroxamic acid (SAHA) has been reported to exhibit anticancer activities in various cancer cell types, but as yet there are few reports on the anticanc...
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Article
Open AccessPrevalence and predictors of loss of wild type BRCA1 in estrogen receptor positive and negative BRCA1-associated breast cancers
The majority of breast cancers that occur in BRCA1 mutation carriers (BRCA1 carriers) are estrogen receptor-negative (ER-). Therefore, it has been suggested that ER negativity is intrinsic to BRCA1 cancers and re...
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Article
Open AccessAccelerated partial breast irradiation using multicatheter brachytherapy for select early-stage breast cancer: local control and toxicity
To investigate the efficacy and safety of accelerated partial breast irradiation (APBI) via high-dose-rate (HDR) multicatheter interstitial brachytherapy for early-stage breast cancer.
