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Article
Cucurbitacin-I exhibits anticancer activity by inducing apoptosis in SKOV3 human ovarian cancer cells
Cucurbitacin-I is a natural cell-permeable triterpenoid compound isolated from Cucurbitaceae and Cruciferae. The pharmacological activity of cucurbitacin-I in human ovarian cancer has been rarely reported.
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Article
Facile synthesis of laser-induced graphene oxide and its humidity sensing properties
In this study, laser-induced graphene oxide (LIGO) was synthesized through a facile liquid-based process involving the introduction of deionized (DI) water onto polyimide (PI) film and subsequent direct laser ...
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Article
Open AccessA multimodal virtual vision platform as a next-generation vision system for a surgical robot
Robot-assisted surgery platforms are utilized globally thanks to their stereoscopic vision systems and enhanced functional assistance. However, the necessity of ergonomic improvement for their use by surgeons ...
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Article
New prognostic model for hospitalized patients with alcoholic cirrhosis and Maddrey’s discriminant function <32
Few studies have investigated the prognosis of patients with non-severe alcoholic hepatitis (Non-SAH). The study aimed to develop a new prognostic model for patients with especially Non-SAH.
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Article
Open AccessMicroplastic induces mitochondrial pathway mediated cellular apoptosis in mussel (Mytilus galloprovincialis) via inhibition of the AKT and ERK signaling pathway
Microplastics (MPs) is an escalating aquatic environmental crisis that poses significant threats to marine organisms, especially mussels. Here, we compare the cumulative toxic effects of the two most abundant ...
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Article
Open AccessCompositional changes in fecal microbiota in a new Parkinson's disease model: C57BL/6-Tg(NSE-haSyn) mice
The gut–brain axis (GBA) in Parkinson's disease (PD) has only been investigated in limited mice models despite dysbiosis of the gut microbiota being considered one of the major treatment targets for neurodegen...
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Article
Effectiveness and complication rates of percutaneous transhepatic fluoroscopy-guided management of common bile duct stones: a single-arm meta-analysis
To perform a systematic review and meta-analysis to determine the success and complication rate of percutaneous transhepatic fluoroscopy-guided management (PTFM) for the removal of common bile duct stones (CBDS).
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Article
Effects of Omega-3 Fatty Acids on Flow-mediated Dilatation and Carotid Intima Media Thickness: A Meta-analysis
To investigate the effects of omega-3 fatty acids on flow-mediated dilatation (FMD) and carotid intima-media thickness (CIMT) and explore the factors influencing these effects.
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Article
Open AccessCovering families of triangles
A cover for a family \({{\mathcal {F}}}\) F of sets in the plane is a set i...
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Open AccessTotal neoadjuvant therapy with short-course radiotherapy Versus long-course neoadjuvant chemoradiotherapy in Locally Advanced Rectal cancer, Korean trial (TV-LARK trial): study protocol of a multicentre randomized controlled trial
For locally advanced rectal cancer (LARC), total neoadjuvant therapy (TNT) may enhance tumour response, reduce recurrence, and improve patient compliance compared to upfront surgery. Recent studies have shown ...
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Article
Open AccessPersonalised circulating tumour DNA assay with large-scale mutation coverage for sensitive minimal residual disease detection in colorectal cancer
Postoperative minimal residual disease (MRD) detection using circulating-tumour DNA (ctDNA) requires a highly sensitive analysis platform. We have developed a tumour-informed, hybrid-capture ctDNA sequencing M...
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Article
Open AccessEnhancing the interferon-γ release assay through omission of nil and mitogen values
To address the limited utility of the interferon (IFN)-γ release assay (IGRA) caused by its variability and inconsistency.
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Article
Open AccessDevelopment of complemented comprehensive networks for rapid screening of repurposable drugs applicable to new emerging disease outbreaks
Computational drug repurposing is crucial for identifying candidate therapeutic medications to address the urgent need for develo** treatments for newly emerging infectious diseases. The recent COVID-19 pand...
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Article
Open AccessGut microbiome associated with low anterior resection syndrome after rectal cancer surgery
This study aimed to assess the likely association of gut microbiome with low anterior resection syndrome (LARS) symptoms. Postoperative stool samples from patients with minor or major LARS after sphincter-pres...
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Article
Open AccessWidespread somatic L1 retrotransposition in normal colorectal epithelium
Throughout an individual’s lifetime, genomic alterations accumulate in somatic cells1–11. However, the mutational landscape induced by retrotransposition of long interspersed nuclear element-1 (L1), a widespread ...
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Article
Safety of early surgery after self-expandable metallic stenting for obstructive left-sided colorectal cancer
Self-expanding metallic stenting (SEMS) is usual for the temporary resolution of obstructive left-sided colorectal cancer (CRC) as a bridge to elective surgery. However, there is no consensus regarding adequat...
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Article
Open AccessCorrection to: Dysbiotic microbiome variation in colorectal cancer patients is linked to lifestyles and metabolic diseases
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Article
Open AccessDistribution of dietary nitrate and its metabolites in rat tissues after 15N-labeled nitrate administration
The reduction pathway of nitrate (NO3−) and nitrite (NO2−) to nitric oxide (NO) contributes to regulating many physiological processes. To examine the rate and extent of dietary nitrate absorption and its reducti...
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Article
Open AccessDysbiotic microbiome variation in colorectal cancer patients is linked to lifestyles and metabolic diseases
Differences in the composition and diversity of the gut microbial communities among individuals are influenced by environmental factors. However, there is limited research on factors affecting microbiome varia...
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Article
Open AccessEnterotypical Prevotella and three novel bacterial biomarkers in preoperative stool predict the clinical outcome of colorectal cancer
A significant proportion of colorectal cancer (CRC) patients suffer from early recurrence and progression after surgical treatment. Although the gut microbiota is considered as a key player in the initiation a...
