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Article
Open AccessDistribution of dietary nitrate and its metabolites in rat tissues after 15N-labeled nitrate administration
The reduction pathway of nitrate (NO3−) and nitrite (NO2−) to nitric oxide (NO) contributes to regulating many physiological processes. To examine the rate and extent of dietary nitrate absorption and its reducti...
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Article
Longitudinal multi-omics analyses of the gut–liver axis reveals metabolic dysregulation in hepatitis C infection and cirrhosis
The gut and liver are connected via the portal vein, and this relationship, which includes the gut microbiome, is described as the gut–liver axis. Hepatitis C virus (HCV) can infect the liver and cause fibrosi...
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Article
Open AccessModerate levels of 5-fluorocytosine cause the emergence of high frequency resistance in cryptococci
The antifungal agent 5-fluorocytosine (5-FC) is used for the treatment of several mycoses, but is unsuitable for monotherapy due to the rapid development of resistance. Here, we show that cryptococci develop r...
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Article
Metformin improves blood glucose by increasing incretins independent of changes in gluconeogenesis in youth with type 2 diabetes
Metformin is the only approved oral agent for youth with type 2 diabetes but its mechanism of action remains controversial. Recent data in adults suggest a primary role for the enteroinsular pathway, but there...
