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Article
Open AccessCompact zinc finger architecture utilizing toxin-derived cytidine deaminases for highly efficient base editing in human cells
Nucleobase editors represent an emerging technology that enables precise single-base edits to the genomes of eukaryotic cells. Most nucleobase editors use deaminase domains that act upon single-stranded DNA an...
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Article
Open AccessMultiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems
A crucial step towards engineering biological systems is the ability to precisely tune the genetic response to environmental stimuli. In the case of Escherichia coli inducible promoters, our incomplete understand...
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Article
Open AccessCommon genetic risk variants identified in the SPARK cohort support DDHD2 as a candidate risk gene for autism
Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder. Large genetically informative cohorts of individuals with ASD have led to the identification of a limited number of common geno...
