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Article
The Relation of Neighborhood Racial and Income Polarity to Preterm Birth Rates in Chicago
To investigate the extent to which spatial social polarization is associated with preterm birth among urban African-American and non-Latinx white women, and whether prenatal care modifies this relationship.
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Article
Open AccessGenetic diversity fuels gene discovery for tobacco and alcohol use
Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of worldwide deaths, respectively, due largely to broad increased risk for disease and injury1–4. These substances are used across the...
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Article
Open AccessIlluminating links between cis-regulators and trans-acting variants in the human prefrontal cortex
Neuropsychiatric disorders afflict a large portion of the global population and constitute a significant source of disability worldwide. Although Genome-wide Association Studies (GWAS) have identified many dis...
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Article
Risk factors for death during newborn and post-newborn hospitalizations among preterm infants
To examine risk factors for mortality among preterm infants during newborn and subsequent hospitalizations, and whether they differ by race/ethnicity.
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Article
Open AccessFocus on your locus with a massively parallel reporter assay
A growing number of variants associated with risk for neurodevelopmental disorders have been identified by genome-wide association and whole genome sequencing studies. As common risk variants often fall within...
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Article
Teen Birth Across Generations Among Non-Latino Whites and African–American Women: The Effect of Race and Neighborhood Income
To examine the extent to which lifelong neighborhood income modifies the generational association of teen birth among White and AA women in Cook County, IL.
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Article
Open AccessLarge-scale GWAS of food liking reveals genetic determinants and genetic correlations with distinct neurophysiological traits
We present the results of a GWAS of food liking conducted on 161,625 participants from the UK-Biobank. Liking was assessed over 139 specific foods using a 9-point scale. Genetic correlations coupled with struc...
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Article
Common variants contribute to intrinsic human brain functional networks
The human brain forms functional networks of correlated activity, which have been linked with both cognitive and clinical outcomes. However, the genetic variants affecting brain function are largely unknown. H...
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Article
Inter-center variation in autopsy practices among regional neonatal intensive care units (NICUs)
To characterize infants who underwent autopsy in regional neonatal intensive care units (NICUs) and examine inter-center variability in autopsy completion.
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Article
Withdrawal of artificial nutrition and hydration: a survey of level IV neonatal intensive care units
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Article
Medical and surgical interventions and outcomes for infants with trisomy 18 (T18) or trisomy 13 (T13) at children’s hospitals neonatal intensive care units (NICUs)
To examine characteristics and outcomes of T18 and T13 infants receiving intensive surgical and medical treatment compared to those receiving non-intensive treatment in NICUs.
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Article
Open AccessSystematic analysis of exonic germline and postzygotic de novo mutations in bipolar disorder
Bipolar disorder is a severe mental illness characterized by recurrent manic and depressive episodes. To better understand its genetic architecture, we analyze ultra-rare de novo mutations in 354 trios with bi...
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Article
From base pair to brain
In new research, Smith et al. identify thousands of novel genetic associations with human brain structure and function, including those on the X chromosome, by analyzing ~4,000 MRI-derived traits measured in a...
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Article
Open AccessCommon genetic risk variants identified in the SPARK cohort support DDHD2 as a candidate risk gene for autism
Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder. Large genetically informative cohorts of individuals with ASD have led to the identification of a limited number of common geno...
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Article
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
The overwhelming majority of participants in current genetic studies are of European ancestry. To elucidate disease biology in the East Asian population, we conducted a genome-wide association study (GWAS) wit...
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Article
Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan
While polygenic risk scores (PRSs) are poised to be translated into clinical practice through prediction of inborn health risks1, a strategy to utilize genetics to prioritize modifiable risk factors driving heath...
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Article
GWAS of 165,084 Japanese individuals identified nine loci associated with dietary habits
Dietary habits are important factors in our lifestyle, and confer both susceptibility to and protection from a variety of human diseases. We performed genome-wide association studies for 13 dietary habits incl...
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Article
Open AccessAssociations of autozygosity with a broad range of human phenotypes
In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because...
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Article
Neighborhood Gun Violence and Birth Outcomes in Chicago
To examine the association between gun violence and birth outcomes among women in Chicago.
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Article
Open AccessModifiable sleep-related risk factors in infant deaths in Cook County, Illinois
Each year, approximately 3500 infants in the United States die from sleep-related deaths. The number of sleep-related infant deaths has decreased overall since the 1990s, but disparities in sleep-related death...
