19 Result(s)
within
Jean-François Ghersi-Egea
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Article
Open AccessBlood–brain borders: a proposal to address limitations of historical blood–brain barrier terminology
Many neuroscientists use the term Blood–Brain Barrier (BBB) to emphasize restrictiveness, often equating or reducing the notion of BBB properties to tight junction molecules physically sealing cerebral endothe...
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Brain Fluids, Blood–Brain Interfaces, and Their Involvement in Neuroimmune Regulation During Development and in Adulthood
The homeostasis of brain fluids, which comprise the parenchymal interstitial fluid and the circulating cerebrospinal fluid, is crucial for proper brain development and brain function throughout life. The compo...
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Open AccessVascular network expansion, integrity of blood–brain interfaces, and cerebrospinal fluid cytokine concentration during postnatal development in the normal and jaundiced rat
Severe neonatal jaundice resulting from elevated levels of unconjugated bilirubin in the blood induces dramatic neurological impairment. Central oxidative stress and an inflammatory response have been associat...
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Drug Metabolism at the Blood-Brain and Blood-CSF Barriers
Drug metabolism is in most cases a detoxication process allowing the organism to inactivate and eliminate foreign substances to which it is exposed. While the liver is the main site of drug metabolism, drug me...
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Article
Open AccessThe legacy of Malcolm Beverley Segal (1937–2019) on the science and fields concerned with choroid plexus and cerebrospinal fluid physiology
This article highlights the scientific achievements, professional career, and personal interactions of Malcolm B. Segal who passed away in July this year. Born in 1937 in Goodmayes, Essex, UK, Segal rose to th...
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Article
Barriers to Drug Distribution into the Perinatal and Postnatal Brain
Drug bioavailability to the develo** brain is a major concern in the treatment of neonates and infants as well as pregnant and breast-feeding women. Central adverse drug reactions can have dramatic consequen...
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Open AccessMolecular anatomy and functions of the choroidal blood-cerebrospinal fluid barrier in health and disease
The barrier between the blood and the ventricular cerebrospinal fluid (CSF) is located at the choroid plexuses. At the interface between two circulating fluids, these richly vascularized veil-like structures d...
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Article
Open AccessChanges in the cerebrospinal fluid circulatory system of the develo** rat: quantitative volumetric analysis and effect on blood-CSF permeability interpretation
The cerebrospinal fluid (CSF) circulatory system is involved in neuroimmune regulation, cerebral detoxification, and delivery of various endogenous and exogenous substances. In conjunction with the choroid ple...
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Article
Open AccessThe quest for a better insight into physiology of fluids and barriers of the brain: the exemplary career of Joseph D. Fenstermacher
In June 2014 Dr. Joseph D. Fenstermacher celebrated his 80th birthday, which was honored by the symposium held in New London, NH, USA. This review discusses Fenstermacher’s contribution to the field of fluids ...
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Drug Metabolism at the Blood–Brain and Blood–CSF Barriers
Drug metabolism is in most cases a detoxification process allowing the organism to inactivate and eliminate foreign substances to which it is exposed. While the liver is the main site of drug metabolism, drug-...
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Article
Open AccessComplexity and developmental changes in the expression pattern of claudins at the blood–CSF barrier
The choroid plexus epithelium controls the movement of solutes between the blood and the cerebrospinal fluid. It has been considered as a functionally more immature interface during brain development than in a...
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Article
Open AccessBrain leukocyte infiltration initiated by peripheral inflammation or experimental autoimmune encephalomyelitis occurs through pathways connected to the CSF-filled compartments of the forebrain and midbrain
Cerebrospinal fluid (CSF) has been considered as a preferential pathway of circulation for immune cells during neuroimmune surveillance. In order to evaluate the involvement of CSF-filled spaces in the pathoge...
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In Vitro Models of the Blood–Cerebrospinal Fluid Barrier and Their Use in Neurotoxicological Research
The choroid plexus epithelium forms the interface between the blood and the cerebrospinal fluid. In addition to its barrier function resulting from the presence of tight junctions sealing the epithelial cells ...
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Article
Open AccessProstaglandin E2metabolism in rat brain: Role of the blood-brain interfaces
Prostaglandin E2 (PGE2) is involved in the regulation of synaptic activity and plasticity, and in brain maturation. It is also an important mediator of the central response to inflammatory challenges. The aim of ...
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Neuroprotective and Detoxifying Mechanisms at the Blood-Brain Interfaces
A fine homeostasis of the brain extracellular fluid is required for the neural cells to fulfill their complex physiological fonctions. This homeostasis is achieved and controlled by several mechanisms which pr...
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Are Blood-brain Interfaces Efficient in Protecting the Brain from Reactive Molecules ?
It has been known from more than a century that the central nervous system is isolated from the rest of the body by a barrier between the blood and the brain. The brain is a complex organ, formed by numerous a...
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Article
Organotypic rat brain culture as in vivo-like model system
The goal of the current research was to define an in vitro system that can replace in vivo experimentation but reflects as far as possible aspects of the intact situation of the develo** nervous system of ma...
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Article
EVALUATION OF SUPEROXIDE RADICAL PRODUCTION IN CULTURED NEURONS. EFFECTS OF HYPOXIA AND HYPEROXIA
The formation of oxygen free radicals, especially superoxide and hydroxyl radicals, leads to hypoxic neuronal damage. In an attempt to investigate the infiuence of post-hypoxia reoxygenation in a model of prim...
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Evidence for drug metabolism as a source of reactive species in the brain
Several pathways for reactive species formation involving xenobiotic metabolism exist in the brain. They include oxidative activation by different enzymatic systems like cytochrome P-450 and monoamine oxidases...
