Summary
Several pathways for reactive species formation involving xenobiotic metabolism exist in the brain. They include oxidative activation by different enzymatic systems like cytochrome P-450 and monoamine oxidases, and superoxide radical production issued from reductive xenobiotic metabolism. They may contribute to cellular impairment observed in various physiopathological situations.
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Ghersi-Egea, JF., Livertoux, MH. (1992). Evidence for drug metabolism as a source of reactive species in the brain. In: Emerit, I., Chance, B. (eds) Free Radicals and Aging. EXS, vol 62. Birkhäuser Basel. https://doi.org/10.1007/978-3-0348-7460-1_22
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DOI: https://doi.org/10.1007/978-3-0348-7460-1_22
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