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  1. No Access

    Article

    Sperm chromatin structure and reproductive fitness are altered by substitution of a single amino acid in mouse protamine 1

    Conventional dogma presumes that protamine-mediated DNA compaction in sperm is achieved by electrostatic interactions between DNA and the arginine-rich core of protamines. Phylogenetic analysis reveals several...

    Lindsay Moritz, Samantha B. Schon, Mashiat Rabbani… in Nature Structural & Molecular Biology (2023)

  2. Article

    Open Access

    Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres

    Human shelterin components POT1 and TPP1 form a stable heterodimer that protects telomere ends from ATR-dependent DNA damage responses and regulates telomerase-dependent telomere extension. Mice possess two fu...

    Peili Gu, Shuting Jia, Taylor Takasugi, Valerie M. Tesmer… in Nature Communications (2021)

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  3. No Access

    Article

    Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites

    Meiotic cells invoke breast cancer susceptibility gene 2 (BRCA2) to repair programmed double-stranded DNA breaks and accomplish homologous recombination. The meiosis-specific protein MEILB2 facilitates BRCA2 recr...

    Devon F. Pendlebury, **g**g Zhang… in Nature Structural & Molecular Biology (2021)

  4. Article

    Open Access

    The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells

    Breast cancer susceptibility gene II (BRCA2) is central in homologous recombination (HR). In meiosis, BRCA2 binds to MEILB2 to localize to DNA double-strand breaks (DSBs). Here, we identify BRCA2 and MEILB2-assoc...

    **g**g Zhang, Manickam Gurusaran, Yasuhiro Fujiwara, Kexin Zhang… in Nature Communications (2020)

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  5. No Access

    Article

    Structural biology of telomeres and telomerase

    Telomeres are protein–DNA complexes that protect chromosome ends from illicit ligation and resection. Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric DNA to counter telomere shortening. Hum...

    Eric M. Smith, Devon F. Pendlebury… in Cellular and Molecular Life Sciences (2020)

  6. No Access

    Article

    Dissecting the telomere–inner nuclear membrane interface formed in meiosis

    Structural and functional analyses of human TRF1 in complex with meiosis-specific protein TERB1 reveal the basis for telomere tethering to the inner nuclear membrane and offer insight into the mechanism of dis...

    Devon F Pendlebury, Yasuhiro Fujiwara… in Nature Structural & Molecular Biology (2017)

  7. No Access

    Article

    Finding the end: recruitment of telomerase to telomeres

  8. The ends of linear chromosomes pose two problems to eukaryotic cells: the end-protection problem; and the end-replication problem. End protection is necessary ...

    9. Jayakrishnan Nandakumar, Thomas R. Cech in Nature Reviews Molecular Cell Biology (2013)

  9. No Access

    Article

    The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity

    Using separation-of-function mutations of TPP1 that inhibit telomerase binding while maintaining telomere cap**, a region on the surface of TPP1, the TEL patch, is identified and found to be required for bot...

    Jayakrishnan Nandakumar, Caitlin F. Bell, Ina Weidenfeld, Arthur J. Zaug… in Nature (2012)

  10. No Access

    Article

    Structural basis for nick recognition by a minimal pluripotent DNA ligase

    Chlorella virus DNA ligase, the smallest eukaryotic ligase known, has pluripotent biological activity and an intrinsic nick-sensing function, despite having none of the accessory domains found in cellular liga...

    Pravin A Nair, Jayakrishnan Nandakumar, Paul Smith… in Nature Structural & Molecular Biology (2007)