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  1. Article

    Open Access

    Distinct functions of POT1 proteins contribute to the regulation of telomerase recruitment to telomeres

    Human shelterin components POT1 and TPP1 form a stable heterodimer that protects telomere ends from ATR-dependent DNA damage responses and regulates telomerase-dependent telomere extension. Mice possess two fu...

    Peili Gu, Shuting Jia, Taylor Takasugi, Valerie M. Tesmer… in Nature Communications (2021)

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    Article

    Dissecting the telomere–inner nuclear membrane interface formed in meiosis

    Structural and functional analyses of human TRF1 in complex with meiosis-specific protein TERB1 reveal the basis for telomere tethering to the inner nuclear membrane and offer insight into the mechanism of dis...

    Devon F Pendlebury, Yasuhiro Fujiwara… in Nature Structural & Molecular Biology (2017)

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    Article

    An autoinhibitory helix in the C-terminal region of phospholipase C-β mediates Gαq activation

    By examining the structure of phospholipase C-β, an autoinhibitory helix that interacts with the catalytic core of this enzyme is now identified. Disrupting this interaction enhances basal activity and decreas...

    Angeline M Lyon, Valerie M Tesmer… in Nature Structural & Molecular Biology (2011)