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Article
A machine learning model for ranking candidate HLA class I neoantigens based on known neoepitopes from multiple human tumor types
Tumor neoepitopes presented by major histocompatibility complex (MHC) class I are recognized by tumor-infiltrating lymphocytes (TIL) and are targeted by adoptive T-cell therapies. Identifying which mutant neoe...
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Article
Open AccessAuthor Correction: RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Open AccessMemory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients
T cells targeting shared oncogenic mutations can induce durable tumor regression in epithelial cancer patients. Such T cells can be detected in tumor infiltrating lymphocytes, but whether such cells can be det...
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Article
Open AccessRGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells
Analysis of 501 melanoma exomes revealed RGS7, which encodes a GTPase-accelerating protein (GAP), to be a tumor-suppressor gene. RGS7 was mutated in 11% of melanomas and was found to harbor three recurrent mutati...
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Article
Identification of essential genes for cancer immunotherapy
Somatic gene mutations can alter the vulnerability of cancer cells to T-cell-based immunotherapies. Here we perturbed genes in human melanoma cells to mimic loss-of-function mutations involved in resistance to...
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Protocol
Genetic and Functional Analysis of GRIN2A in Tumor Samples
Ionotropic glutamate receptors (iGluRs) are large integral membrane multi-protein complexes that create ion channels in plasma membranes. Upon binding of receptor specific ligands (e.g., glutamate), increased ...
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Article
Open Access31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one
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Article
Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients
Steven Rosenberg and colleagues report that PD-1 is a biomarker of CD8+ T cells in the blood that recognize mutated neoantigens in melanoma.
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Article
Recurrent inactivating RASA2 mutations in melanoma
Yardena Samuels and colleagues report the analysis of 501 melanoma exomes and the identification of RASA2 as a tumor-suppressor gene mutated in 5% of melanomas. RASA2 mutations led to increased RAS activation, an...
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Article
Open AccessDiversity of mutated antigen recognition by tumor infiltrating lymphocytes from patients with metastatic melanoma
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Article
Open AccessImmunotherapy generates selective pressure for acquisition of immunogenic neoantigens in escape tumors
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Article
Open AccessSelection of circulating PD-1+ lymphocytes from cancer patients enriches for tumor-reactive and mutation-specific lymphocytes
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Article
Open AccessDiscovery and characterization of an immunogenic neoantigen in a patient with metastatic triple negative breast cancer
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Article
Open AccessDurable complete response in a patient with metastatic melanoma following adoptive transfer of autologous T cells recognizing 10 mutated tumor antigens
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Article
Open AccessIdentification of mutation-specific tumor infiltrating lymphocytes from metastatic ovarian cancer
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Article
Open AccessPersonalized immunotherapy for non-small cell lung cancer through identification of tumor-specific mutations by next generation sequencing and adoptive transfer of tumor infiltrating lymphocytes that recognize neoantigens
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Article
Open AccessUnique neoantigens expressed by melanomas and common epithelial cancers presented by multiple HLA alleles can be efficiently identified utilizing peptide prediction algorithms
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Article
Open AccessAdoptively transferred tumor-infiltrating T cells target somatic cancer mutations in a human papillomavirus+ cancer patient with complete tumor regression
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Article
Open AccessStudy and characterization of mutated antigen specific T cells isolated from fresh tumor and peripheral lymphocytes in cancer patients
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Article
Open AccessTetramer based approach for efficient identification and isolation of neo-antigen specific CD8 T cells from peripheral blood (PBL) of patients with metastatic cancers
