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Article
A machine learning model for ranking candidate HLA class I neoantigens based on known neoepitopes from multiple human tumor types
Tumor neoepitopes presented by major histocompatibility complex (MHC) class I are recognized by tumor-infiltrating lymphocytes (TIL) and are targeted by adoptive T-cell therapies. Identifying which mutant neoe...
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Protocol
Genetic and Functional Analysis of GRIN2A in Tumor Samples
Ionotropic glutamate receptors (iGluRs) are large integral membrane multi-protein complexes that create ion channels in plasma membranes. Upon binding of receptor specific ligands (e.g., glutamate), increased ...
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Article
Open Access31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part one
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Article
Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients
Steven Rosenberg and colleagues report that PD-1 is a biomarker of CD8+ T cells in the blood that recognize mutated neoantigens in melanoma.
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Article
Open AccessDiversity of mutated antigen recognition by tumor infiltrating lymphocytes from patients with metastatic melanoma
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Article
Open AccessSelection of circulating PD-1+ lymphocytes from cancer patients enriches for tumor-reactive and mutation-specific lymphocytes
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Article
Open AccessDiscovery and characterization of an immunogenic neoantigen in a patient with metastatic triple negative breast cancer
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Article
Open AccessDurable complete response in a patient with metastatic melanoma following adoptive transfer of autologous T cells recognizing 10 mutated tumor antigens
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Article
Open AccessIdentification of mutation-specific tumor infiltrating lymphocytes from metastatic ovarian cancer
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Article
Open AccessPersonalized immunotherapy for non-small cell lung cancer through identification of tumor-specific mutations by next generation sequencing and adoptive transfer of tumor infiltrating lymphocytes that recognize neoantigens
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Article
Open AccessUnique neoantigens expressed by melanomas and common epithelial cancers presented by multiple HLA alleles can be efficiently identified utilizing peptide prediction algorithms
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Article
Open AccessHigh frequency CD8+PD-1+ TCR clonotypes isolated from fresh melanomas display anti-tumor activity
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Article
Open AccessStudy and characterization of mutated antigen specific T cells isolated from fresh tumor and peripheral lymphocytes in cancer patients
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Article
Exon capture analysis of G protein-coupled receptors identifies activating mutations in GRM3 in melanoma
Yardena Samuels and colleagues sequenced G protein-coupled receptors in 11 melanoma samples and report a comprehensive map of somatic variants in the GPCR gene family. They find frequent mutations in GRM3, whi...
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Article
Exome sequencing identifies GRIN2A as frequently mutated in melanoma
Yardena Samuels and colleagues report the sequencing of 14 melanoma exomes. They identify a recurrent mutation in TRRAP in 4% of cases as well as mutations in GRIN2A in 33% of tumors.
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Article
Analysis of the tyrosine kinome in melanoma reveals recurrent mutations in ERBB4
Yardena Samuels and colleagues report a mutational analysis of the protein tyrosine kinase family in cutaneous metastatic melanoma. They find ERBB4 mutations in 19% of tumors and show that these mutations enhance...
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Article
Analysis of the matrix metalloproteinase family reveals that MMP8 is often mutated in melanoma
Yardena Samuels and colleagues report a mutational analysis of the matrix metalloproteinase gene family in cutaneous metastatic melanoma. They find frequent somatic mutations in MMP8 and present functional eviden...
