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Open AccessAuthor Correction: RGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
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Article
Open AccessRGS7 is recurrently mutated in melanoma and promotes migration and invasion of human cancer cells
Analysis of 501 melanoma exomes revealed RGS7, which encodes a GTPase-accelerating protein (GAP), to be a tumor-suppressor gene. RGS7 was mutated in 11% of melanomas and was found to harbor three recurrent mutati...
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Article
Recurrent inactivating RASA2 mutations in melanoma
Yardena Samuels and colleagues report the analysis of 501 melanoma exomes and the identification of RASA2 as a tumor-suppressor gene mutated in 5% of melanomas. RASA2 mutations led to increased RAS activation, an...
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Article
Signatures of historical demography and pathogen richness on MHC class I genes
The extreme polymorphism of MHC class I has been argued to be driven by balancing selection from pathogens, with the prediction that populations exposed to a wider variety of diseases should have higher diversity...