Skip to main content

3 Result(s)

within Janos Ludwig Remove this filter Science, multidisciplinary Remove this filter

and

  1. Article

    Open Access

    NUDT2 initiates viral RNA degradation by removal of 5′-phosphates

    While viral replication processes are largely understood, comparably little is known on cellular mechanisms degrading viral RNA. Some viral RNAs bear a 5′-triphosphate (PPP-) group that impairs degradation by ...

    Beatrice T. Laudenbach, Karsten Krey, Quirin Emslander… in Nature Communications (2021)

    Download PDF (1374 KB) View Article

  2. No Access

    Article

    Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates

    The innate immune receptor RIG-I is shown to sense 5′-diphosphate RNAs as found in some viral genomes in addition to its well characterized activation by RNAs bearing 5′-triphosphate moieties.

    Delphine Goubau, Martin Schlee, Safia Deddouche, Andrea J. Pruijssers… in Nature (2014)

  3. No Access

    Article

    cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

    Cytosolic DNA induces type I interferon via activation of STING; the immediate STING activator is produced by the recently identified DNA sensor cGAS and is shown here to be an unorthodox cyclic dinucleotide h...

    Andrea Ablasser, Marion Goldeck, Taner Cavlar, Tobias Deimling, Gregor Witte… in Nature (2013)