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  1. Article

    Open Access

    Intestinal intraepithelial lymphocyte activation promotes innate antiviral resistance

    Unrelenting environmental challenges to the gut epithelium place particular demands on the local immune system. In this context, intestinal intraepithelial lymphocytes (IEL) compose a large, highly conserved T...

    Mahima Swamy, Lucie Abeler-Dörner, James Chettle, Tanel Mahlakõiv… in Nature Communications (2015)

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    Article

    Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates

    The innate immune receptor RIG-I is shown to sense 5′-diphosphate RNAs as found in some viral genomes in addition to its well characterized activation by RNAs bearing 5′-triphosphate moieties.

    Delphine Goubau, Martin Schlee, Safia Deddouche, Andrea J. Pruijssers… in Nature (2014)

  3. Article

    PYHIN proteins: center stage in DNA sensing

    Innate immune responses to pathogens are often triggered by nucleic acids, including DNA delivered to the cytoplasm of cells. IFI16 is a newly identified cytoplasmic DNA sensor that induces the transcription o...

    Delphine Goubau, Jan Rehwinkel, Caetano Reis e Sousa in Nature Immunology (2010)

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  4. Article

    RIG-I has guts: Identification of a role for RIG-I in colitis development

    Mayra Solis, Delphine Goubau, John Hiscott in Cell Research (2007)

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