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  1. Article

    Age-dependent susceptibility to reovirus encephalitis in mice is influenced by maturation of the type-I interferon response

    Infants and young children are particularly susceptible to viral encephalitis; however, the mechanisms are unknown. We determined the age-dependent contribution of innate and adaptive immune functions to reovi...

    Allen G Wu, Andrea J Pruijssers, Judy J Brown… in Pediatric Research (2018)

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    Reovirus

    Mammalian orthoreoviruses are nonenveloped dsRNA viruses that infect most mammals including humans and mice. Following oral inoculation of newborn mice, reovirus disseminates to the CNS and produces a nonletha...

    Andrea J. Pruijssers, Terence S. Dermody in Neurotropic Viral Infections (2016)

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    Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5′-diphosphates

    The innate immune receptor RIG-I is shown to sense 5′-diphosphate RNAs as found in some viral genomes in addition to its well characterized activation by RNAs bearing 5′-triphosphate moieties.

    Delphine Goubau, Martin Schlee, Safia Deddouche, Andrea J. Pruijssers… in Nature (2014)