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Article
Open AccessChange in Mindfulness Profiles After Mindfulness-Based Cognitive Therapy for Major Depressive Disorder
Mindfulness-Based Cognitive Therapy (MBCT) reduces recurrence and current depressive symptoms in patients with major depressive disorder (MDD). To understand how and for whom MBCT works, a person-centered appr...
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Article
Oral esketamine in patients with treatment-resistant depression: a double-blind, randomized, placebo-controlled trial with open-label extension
About one-third of patients with depression do not achieve adequate response to current treatment options. Although intravenous and intranasal administrations of (es)ketamine have shown antidepressant properti...
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Article
Open AccessLatent Profile Analysis of the Five Facet Mindfulness Questionnaire (FFMQ) Subscales in a Naturalistic Sample of Patients with Past or Present Major Depression: A Replication and Extension Study
Mindfulness is a multifaceted concept which might be best captured by person-centered profiles rather than by variable-centered assessment of its subcomponents. Patients with different mindfulness profiles may...
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Article
Open AccessClosing the gap between screening and depression prevention: a qualitative study on barriers and facilitators from the perspective of public health professionals in a school-based prevention approach
The prevalence of depression has increased among adolescents in western countries. Prevention is needed to reduce the number of adolescents who experience depression and to avoid negative consequences, includi...
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Open AccessThe effect of mindfulness-based cognitive therapy on rumination and a task-based measure of intrusive thoughts in patients with bipolar disorder
Preliminary evidence suggests that Mindfulness-Based Cognitive Therapy (MBCT) is a promising treatment for bipolar disorder (BD). A proposed working mechanism of MBCT in attenuating depressive symptoms is redu...
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Open AccessrTMS combined with CBT as a next step in antidepressant non-responders: a study protocol for a randomized comparison with current antidepressant treatment approaches
Major depressive disorder (MDD) is one of the most common psychiatric disorders, however, current treatment options are insufficiently effective for about 35% of patients, resulting in treatment-resistant depr...
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Article
Open AccessA randomized controlled trial of cognitive control training (CCT) as an add-on treatment for late-life depression: a study protocol
Already a major health concern, late-life depression (LLD) is expected to form an increasing problem in the aging population. Moreover, despite current treatments, LLD is associated with a poor long-term progn...
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Article
Open AccessTricyclic antidepressants for major depressive disorder: a comprehensive evaluation of current practice in the Netherlands
Traditionally tricyclic antidepressants (TCAs) have an important place in treatment of major depressive disorder (MDD). Today, often other antidepressant medications are considered as first step in the pharmac...
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Article
Een goed gesprek over het afbouwen van antidepressiva
Steeds meer mensen gebruiken langdurig antidepressiva en niet alleen patiënten aarzelen om te stoppen. Meestal heeft de patiënt noch de huisarts duidelijk voor ogen wat er precies aan de orde moe...
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Open AccessLongitudinal effects of rTMS on neuroplasticity in chronic treatment-resistant depression
Major depressive disorder (MDD) is amongst the most prevalent of psychiatric disorders. Unfortunately, a third of patients will not respond to conventional treatments and suffer from treatment-resistant depres...
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Article
Open AccessExercise enhances: study protocol of a randomized controlled trial on aerobic exercise as depression treatment augmentation
Major depressive disorder (MDD) is a considerable public health concern. In spite of evidence-based treatments for MDD, many patients do not improve and relapse is common. Therefore, improving treatment outcom...
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Article
Open AccessAn exploration of the conditions for deploying self-management strategies: a qualitative study of experiential knowledge in depression
Living with recurrent, and/or chronic depression requires long-term management in addition to active co** on a day-to-day basis. Previous research on long-term management, and co** with depression mainly f...
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Open AccessEffects of Mindfulness-Based Cognitive Therapy on a Behavioural Measure of Rumination in Patients with Chronic, Treatment-Resistant Depression
It has been found that Mindfulness-based cognitive therapy (MBCT) reduces rumination in remitted and currently depressed patients. However, less is known about the effects of MBCT on rumination in chronically ...
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Article
Open AccessDiscontinuation of antidepressant medication in primary care supported by monitoring plus mindfulness-based cognitive therapy versus monitoring alone: design and protocol of a cluster randomized controlled trial
Antidepressant use continues to rise, mainly explained by an increase in the proportion of patients receiving long term treatment. Although treatment guidelines recommend discontinuation after sustained remiss...
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Article
Open AccessLower versus higher frequency of sessions in starting outpatient mental health care and the risk of a chronic course; a naturalistic cohort study
An adequate frequency of treatment might be a prerequisite for a favorable outcome. Unfortunately, there is a diversity of factors that interfere with an adequate frequency of sessions. This occurs especially ...
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Article
Open AccessEffectiveness of a self-management training for patients with chronic and treatment resistant anxiety or depressive disorders on quality of life, symptoms, and empowerment: results of a randomized controlled trial
Anxiety and depressive disorders are common mental disorders. A substantial part of patients does not achieve symptomatic remission after treatment in specialized services. Current care as usual (CAU) for thes...
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Article
ADHD symptoms in adults with delayed sleep phase disorder
The aims of the study are to investigate the prevalence of ADHD in delayed sleep phase disorder (DSPD) patients and to explore the relationship between circadian phase and ADHD symptoms, using the dim light me...
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Article
Open AccessBehavioural activation by mental health nurses for late-life depression in primary care: a randomized controlled trial
Depressive symptoms are common in older adults. The effectiveness of pharmacological treatments and the availability of psychological treatments in primary care are limited. A behavioural approach to depressio...
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Article
Open AccessInvestigating the (cost-) effectiveness of attention bias modification (ABM) for outpatients with major depressive disorder (MDD): a randomized controlled trial protocol
Despite the range of available, evidence-based treatment options for Major Depressive Disorder (MDD), the rather low response and remission rates suggest that treatment is not optimal, yet. Computerized attent...
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Article
Open AccessLong-term disability in anxiety disorders
This longitudinal study aims to investigate differences in long-term disability between social anxiety disorder (SAD), panic disorder with agoraphobia (PDA), panic disorder without agoraphobia (PD), generalize...
