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Article
Open AccessAlpha peak frequency-based Brainmarker-I as a method to stratify to pharmacotherapy and brain stimulation treatments in depression
Biomarkers predicting treatment outcome in major depressive disorder could enhance clinical improvement. Here this observational and prospective accuracy study investigates whether an age- and sex-normalized e...
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Article
Open AccessrTMS combined with CBT as a next step in antidepressant non-responders: a study protocol for a randomized comparison with current antidepressant treatment approaches
Major depressive disorder (MDD) is one of the most common psychiatric disorders, however, current treatment options are insufficiently effective for about 35% of patients, resulting in treatment-resistant depr...
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Article
Open AccessIs a Negative Attentional Bias in Individuals with Autism Spectrum Disorder Explained by Comorbid Depression? An Eye-Tracking Study
Heightened attention towards negative information is characteristic of depression. Evidence is emerging for a negative attentional bias in Autism spectrum disorder (ASD), perhaps driven by the high comorbidity...
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Article
Open AccessADHD symptoms in healthy adults are associated with stressful life events and negative memory bias
Stressful life events, especially Childhood Trauma, predict ADHD symptoms. Childhood Trauma and negatively biased memory are risk factors for affective disorders. The association of life events and bias with A...
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Article
Childhood abuse and deprivation are associated with distinct sex-dependent differences in brain morphology
Childhood adversity (CA) has been associated with long-term structural brain alterations and an increased risk for psychiatric disorders. Evidence is emerging that subtypes of CA, varying in the dimensions of ...
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Article
Coherence Between Attentional and Memory Biases in Sad and Formerly Depressed Individuals
Cognitive theories assume a uniform processing bias across different samples, but the empirical support for this claim is rather weak and inconsistent. Therefore, coherence between biases across different cogn...
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Can Memory Bias be Modified? The Effects of an Explicit Cued-Recall Training in Two Independent Samples
Cognitive bias modification (CBM) has been found to be effective in modifying information-processing biases and in reducing emotional reactivity to stress. Although modification of attention and interpretation...
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Open AccessApproach and Avoidance of Emotional Faces in Happy and Sad Mood
Since the introduction of the associative network theory, mood-congruent biases in emotional information processing have been established in individuals in a sad and happy mood. Research has concentrated on me...
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Sex Modulates the Interactive Effect of the Serotonin Transporter Gene Polymorphism and Childhood Adversity on Hippocampal Volume
The common genetic variation of the serotonin transporter-linked polymorphic region (5-HTTLPR) has been related to depressive symptoms, in particular after stressful life events. Although it has been investiga...
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Article
Open AccessPresymptomatic DNA Testing in BRCA1/2. Invited reactions from the field on the van Oostrom and Tibben paper
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Open AccessA Counselling Model for BRCA1/2 Genetic Susceptibility Testing
When BRCA1/2 genetic susceptibility testing was introduced in the clinic in the mid-nineties, the "Huntington protocol" was used in the counselling of individuals applying for genetic testing. This protocol inclu...
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Article
Kijken in de glazen bolerfelijkheid voorspellende diagnostiek erfelijke borst- en ovariumkanker
Voorspellen of je in de toekomst mogelijk een ernstige ziekte zoals kanker zult krijgen is geen science fiction meer. Sinds enkele jaren kunnen mensen uit families waar een afwijkend gen is gevonden laten onde...