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N-2-mercaptopropionylglycine, a Scavanger of Reactive Oxygen Species, does not Modify the Early Antiarrhythmic Effect of Ischaemic Preconditioning in Anaesthetised Dogs
Objective: The possible involvement of reactive oxygen species (ROS) in the protective effects of ischaemic preconditioning (PC) against arrhythmias was examined in anaesthetised dogs usi...
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Chapter
Exercise and Delayed Preconditioning in the Protection of the Heart against Ventricular Arrhythmias: Crucial Role of Nitric Oxide
Ischaemic preconditioning results not only in a reduction in myocardial ischaemic damage but also a marked suppression of those ventricular arrhythmias that result from a prolonged period of ischaemia and repe...
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Article
Isosorbide-2-Mononitrate Reduces the Consequences of Myocardial Ischaemia, Including Arrhythmia Severity: Implications for Preconditioning
The effects of the intracoronary administration of isosorbide-2-mononitrate (ISMN; 3 μg kg−1 min−1), a major metabolite of isosorbide dinitrate, were examined in chloralose-urethane anaesthetized dogs before and ...
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Article
Atrial Natriuretic Peptide Reduces the Severe Consequences of Coronary Artery Occlusion in Anaesthetized Dogs
The aim of the present study was to examine the effects of atrial natriuretic peptide (ANP) on the responses to coronary artery occlusion. In chloralose-urethane anaesthetised mongrel dogs either saline (contr...
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Chapter
Early and Delayed Protection Against Ventricular Arrhythmias Induced by Preconditioning
Ischemic preconditioning, induced by brief periods of coronary artery occlusion, results not only in a reduction in myocardial ischemic damage but also in suppression of those life-threatening ventricular arrh...
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Article
Delayed cardioprotection is associated with the sub-cellular relocalisation of ventricular protein kinase Cɛ, but not p42/44MAPK
Both noradrenaline administration to rats and rapid cardiac pacing in dogs induces delayed protection of the heart against ischaemia-induced ventricular arrhythmias. In an attempt to establish molecular mechan...
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Chapter
Delayed cardioprotection is associated with the sub-cellular relocalisation of ventricular protein kinase Cε, but not p42/44MAPK
Both noradrenaline administration to rats and rapid cardiac pacing in dogs induces delayed protection of the heart against ischaemia-induced ventricular arrhythmias. In an attempt to establish molecular mechan...
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Chapter
Delayed Ischemic Preconditioning Induced by Drugs and by Cardiac Pacing
Recent evidence already summarized in this volume (chapter 13) has revealed the exciting possibility that a heart can be protected several hours after a preconditioning stimulus induced, for example, by short ...
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Chapter
Ischemic Preconditioning Markedly Reduces the Severity of Ischemia and Reperfusion-Induced Arrhythmias: Role of Endogenous Myocardial Protective Substances
It could be argued that an even more important manifestation of ischemic tolerance resulting from ischemic preconditioning than the reduction in infarct size is the profound reduction in the severity of life-t...
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Article
Ischaemic preconditioning in the rat heart: The role of G-proteins and adrenergic stimulation
Since recent findings indicate the involvement of G-proteins in the mechanisms of ischaemic preconditioning (PC), the present study was aimed to investigate the role of adrenergic mechanisms, such as G-protein...
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Ischaemic preconditioning in the rat heart: The role of G-proteins and adrenergic stimulation
Since recent findings indicate the involvement of G-proteins in the mechanisms of ischaemic preconditioning (PC), the present study was aimed to investigate the role of adrenergic mechanisms, such as G-protein...
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Chapter
Preconditioning: An Early Protective Response to Myocardial Ischaemia
Recently there has been a great deal of interest in the concept that myocardial cells are capable of rapidly adapting to brief periods of stress, such as ischaemia, in a manner that is protective against longe...
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Chapter
Platelet-derived Substances in Acute Myocardial Injury
The use of the term ‘current of injury’ may give rise to some misunder-standing. In classical studies on cardiac electrophysiology, part of the heart was deliberately injured by, e.g. locally applying heat, me...
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Article
The effects of chronic lead treatment and hypertension on the severity of cardiac arrhythmias induced by coronary artery occlusion or by noradrenaline in anaesthetised rats
The aim of this study was to investigate whether chronic (3 months) lead (250 or l000ppm), administered as lead acetate in the drinking water, commencing either after weaning (in normotensive or spontaneously ...
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Chapter
Modification of the Thromboxane/Prostacyclin Balance as an Approach to Antiarrhythmic Therapy During Myocardial Ischaemia and Reperfusion; The Concept of Endogenous Antiarrhythmic Substances
Most of the standard approaches to antiarrhythmic therapy in myocardial ischaemia are covered elsewhere in this symposium. They include administration of drugs with various mechanisms of action that have been ...
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Chapter
Inhibitors of the Slow Calcium Current and Early Ventricular Arrhythmias
The effects of ‘calcium antagonist’ drugs on cardiac muscle are due to interference with those ‘slow channels’ in the cell membrane through which Ca2+ ions enter the cell (for example, during the plateau phase of...
