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Article
Open AccessThe reverse mode of the Na+/Ca2+ exchanger contributes to the pacemaker mechanism in rabbit sinus node cells
Sinus node (SN) pacemaking is based on a coupling between surface membrane ion-channels and intracellular Ca2+-handling. The fundamental role of the inward Na+/Ca2+ exchanger (NCX) is firmly established. However,...
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Article
Open AccessThe development of L-type Ca2+ current mediated alternans does not depend on the restitution slope in canine ventricular myocardium
Cardiac alternans have crucial importance in the onset of ventricular fibrillation. The early explanation for alternans development was the voltage-driven mechanism, where the action potential (AP) restitution...
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Article
Open AccessAuthor Correction: Increased Ca2+ content of the sarcoplasmic reticulum provides arrhythmogenic trigger source in swimming-induced rat athlete’s heart model
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessIncreased Ca2+ content of the sarcoplasmic reticulum provides arrhythmogenic trigger source in swimming-induced rat athlete’s heart model
Sudden cardiac death among top athletes is very rare, however, it is 2–4 times more frequent than in the age-matched control population. In the present study, the electrophysiological consequences of long-term...
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Article
[Ca2+]i-induced augmentation of the inward rectifier potassium current (IK1) in canine and human ventricular myocardium
The inward rectifier K+ current (IK1) plays an important role in terminal repolarization and stabilization of the resting potential in cardiac cells. Although IK1 was shown to be sensitive to changes in intracell...
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Article
Open AccessEffects of diclofenac on ventricular muscle repolarization: proarrhythmic implications
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Article
Open AccessIon channels alteration in dilated cardiomyopathy in human heart
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Article
Open AccessActivation of the Poly(ADP-Ribose) Polymerase Pathway in Human Heart Failure
Poly(ADP-ribose) polymerase (PARP) activation has been implicated in the pathogenesis of acute and chronic myocardial dysfunction and heart failure. The goal of the present study was to investigate PARP activa...
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Article
Calpain-1-sensitive myofibrillar proteins of the human myocardium
Calpain-1 is a ubiquitous intracellular Ca2+-activated protease, which has been implicated in the pathogenesis of reversible myocardial depression (i.e. myocardial stunning) that follows ischemia and reperfusion ...
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Exercise and Delayed Preconditioning in the Protection of the Heart against Ventricular Arrhythmias: Crucial Role of Nitric Oxide
Ischaemic preconditioning results not only in a reduction in myocardial ischaemic damage but also a marked suppression of those ventricular arrhythmias that result from a prolonged period of ischaemia and repe...
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Article
Calcium-Dependent Vasorelaxant Capacity of Levosimendan in Porcine and Human Epicardial Coronary Artery Preparations
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Article
Isosorbide-2-Mononitrate Reduces the Consequences of Myocardial Ischaemia, Including Arrhythmia Severity: Implications for Preconditioning
The effects of the intracoronary administration of isosorbide-2-mononitrate (ISMN; 3 μg kg−1 min−1), a major metabolite of isosorbide dinitrate, were examined in chloralose-urethane anaesthetized dogs before and ...
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Article
Atrial Natriuretic Peptide Reduces the Severe Consequences of Coronary Artery Occlusion in Anaesthetized Dogs
The aim of the present study was to examine the effects of atrial natriuretic peptide (ANP) on the responses to coronary artery occlusion. In chloralose-urethane anaesthetised mongrel dogs either saline (contr...
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Article
Pharmacological Modification of the Dispersion of Repolarization in the Heart: Importance of the M Cells
Summary. Several in vitro and in vivo investigations have provided data supporting the existence of M cells in the deep subepicardial layers of the ventricles in a number of species. Characterized by unique el...
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Chapter
Early and Delayed Protection Against Ventricular Arrhythmias Induced by Preconditioning
Ischemic preconditioning, induced by brief periods of coronary artery occlusion, results not only in a reduction in myocardial ischemic damage but also in suppression of those life-threatening ventricular arrh...
