-
Article
Open AccessAssociations of genome-wide and regional autozygosity with 96 complex traits in old order Amish
Background: Autozygosity, the proportion of the genome that is homozygous by descent, has been associated with variation in multiple health-related traits impacting evolutionary fitness. Autozygosity (FROH) is ty...
-
Article
Open AccessWhole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program
The genetic determinants of fasting glucose (FG) and fasting insulin (FI) have been studied mostly through genome arrays, resulting in over 100 associated variants. We extended this work with high-coverage who...
-
Article
Open AccessChromosome Xq23 is associated with lower atherogenic lipid concentrations and favorable cardiometabolic indices
Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in large sample sizes. We now ana...
-
Article
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
-
Article
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
Body-fat distribution is a risk factor for adverse cardiovascular health consequences. We analyzed the association of body-fat distribution, assessed by waist-to-hip ratio adjusted for body mass index, with 22...
-
Article
Open AccessDeep-coverage whole genome sequences and blood lipids among 16,324 individuals
Large-scale deep-coverage whole-genome sequencing (WGS) is now feasible and offers potential advantages for locus discovery. We perform WGS in 16,324 participants from four ancestries at mean depth >29X and an...
-
Article
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
In the version of this article originally published, one of the two authors with the name Wei Zhao was omitted from the author list and the affiliations for both authors were assigned to the single Wei Zhao in...
-
Article
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
In the published version of this paper, the name of author Emanuele Di Angelantonio was misspelled. This error has now been corrected in the HTML and PDF versions of the article.
-
Article
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, noncoding variants fro...
-
Article
Rare and low-frequency coding variants alter human adult height
Height is a highly heritable, classic polygenic trait with approximately 700 common associated variants identified through genome-wide association studies so far. Here, we report 83 height-associated coding va...
-
Article
Drift and benthic invertebrate responses to stepwise and abrupt increases in non-scouring flow
We conducted two experiments to assess drift and benthic invertebrate responses to stepwise and abrupt changes in non-scouring flow in gravel-bed experimental streams. Intuitively, a stepwise flow increase sho...
-
Reference Work Entry In depth
Water, water quality, water supply
-
Article
Decomposition rates and phosphorus concentrations of purple Loosestrife (Lythrum salicaria) and Cattail (Typha spp.) in fourteen Minnesota wetlands
Purple Loosestrife is rapidly displacing native vegetation in North American wetlands. Associated changes in wetland plant communities are well understood. Effects of Loosestrife invasion on nutrient cycling a...
-
Article
Improving lake riparian source area management using surface and subsurface runoff indices
Sensitivity indices, which rank factors pertinent to surface and subsurface runoff pathways, were used to identify phosphorus source areas in riparian zones of 15 northern Minnesota lakes. Watershed models wer...
-
Article
Litter processing in diffuse and conduit springs
We used bedrock geology and prior water chemistry data to classify and choose 4 conduit and 4 diffuse flow springs in a karst region of southeast Minnesota. Decomposition processes and chemical/physical condit...
-
Article
The combined effects of chlorine and ammonia on litter breakdown in outdoor experimental streams
The response of Potamogeton crispus L. breakdown to controlled doses of different levels of chlorine and chlorine + ammonia was investigated over two years in outdoor experimental streams. In 1985, downstream rif...
-
Article
Use of experimental ecosystems in regulatory decision making
Tiered testing for the effects of chemicals on aquatic ecosystems has begun to include tests at the ecosystem level as a component in pesticide regristration. Because such tests are expensive, regulators and i...
-
Chapter
Biomonitoring: Closing the Loop in the Environmental Sciences
For the purposes of this chapter we define biomonitoring as the analysis of the performance of living systems structured to provide essential information for decision making. Although some form of biomonitoring h...
-
Article
The longitudinal distribution of riverine benthos: A river dis-continuum?
We used several techniques to analyze 10–11 collections from each of 13 stations along a mountain stream gradient to examine the hypothesis that there was a statistically significant (p < 0.05) uniform downstr...
-
Article
The environmental audit. I. Concepts
Extensive criticism of water quality monitoring programs has developed as costs are compared with the benefits produced by monitoring efforts. Collecting water quality data while develo** understanding of th...
