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Open AccessEvaluating genomic signatures of aging in brain tissue as it relates to Alzheimer’s disease
Telomere length (TL) attrition, epigenetic age acceleration, and mitochondrial DNA copy number (mtDNAcn) decline are established hallmarks of aging. Each has been individually associated with Alzheimer’s demen...
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Open AccessAssociations of genome-wide and regional autozygosity with 96 complex traits in old order Amish
Background: Autozygosity, the proportion of the genome that is homozygous by descent, has been associated with variation in multiple health-related traits impacting evolutionary fitness. Autozygosity (FROH) is ty...
