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Open AccessDiversity and dissemination of viruses in pathogenic protozoa
Viruses are the most abundant biological entities on Earth and play a significant role in the evolution of many organisms and ecosystems. In pathogenic protozoa, the presence of viruses has been linked to an i...
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Article
Open AccessWhole-genome sequencing of Schistosoma mansoni reveals extensive diversity with limited selection despite mass drug administration
Control and elimination of the parasitic disease schistosomiasis relies on mass administration of praziquantel. Whilst these programmes reduce infection prevalence and intensity, their impact on parasite trans...
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Open AccessThe Phlebotomus papatasi systemic transcriptional response to trypanosomatid-contaminated blood does not differ from the non-infected blood meal
Leishmaniasis, caused by parasites of the genus Leishmania, is a disease that affects up to 8 million people worldwide. Parasites are transmitted to human and animal hosts through the bite of an infected sand fly...
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Open AccessGenomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm
Haemonchus contortus is a globally distributed and economically important gastrointestinal pathogen of small ruminants and has become a key nematode model for studying anthelmintic resistance and other parasite-s...
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Open AccessEvaluation of whole genome amplification and bioinformatic methods for the characterization of Leishmania genomes at a single cell level
Here, we report a pilot study paving the way for further single cell genomics studies in Leishmania. First, the performances of two commercially available kits for Whole Genome Amplification (WGA), PicoPLEX and R...
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Article
Open AccessSex chromosome evolution in parasitic nematodes of humans
Sex determination mechanisms often differ even between related species yet the evolution of sex chromosomes remains poorly understood in all but a few model organisms. Some nematodes such as Caenorhabditis elegan...
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Open AccessPopulation genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus
Infections with helminths cause an enormous disease burden in billions of animals and plants worldwide. Large scale use of anthelmintics has driven the evolution of resistance in a number of species that infec...
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Molecular Evolution and Phylogeny of Leishmania
The genus Leishmania was first described in 1903 for the parasite Leishmania donovani, but many additional species have been described since then. Although recent hierarchical taxonomic schemes have increasingly ...
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Open AccessThe genome of Leishmania adleri from a mammalian host highlights chromosome fission in Sauroleishmania
Control of pathogens arising from humans, livestock and wild animals can be enhanced by genome-based investigation. Phylogenetically classifying and optimal construction of these genomes using short sequence r...
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Article
Open AccessPlasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution
The genome sequences of the neglected human-infective malaria species Plasmodium malariae and P. ovale provide new insights into their biology that are pertinent to understanding their epidemiology and to the bro...
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Open AccessComparative genomics of canine-isolated Leishmania (Leishmania) amazonensis from an endemic focus of visceral leishmaniasis in Governador Valadares, southeastern Brazil
Leishmaniasis is a highly diverse group of diseases caused by kinetoplastid of the genus Leishmania. These parasites are taxonomically diverse, with human pathogenic species separated into two subgenera according...
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Article
Open AccessAn expressed, endogenous Nodavirus-like element captured by a retrotransposon in the genome of the plant parasitic nematode Bursaphelenchus xylophilus
Recently, nematode viruses infecting Caenorhabditis elegans have been reported from the family Nodaviridae, the first nematode viruses described. Here, we report the observation of a novel endogenous viral elemen...
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Open AccessThe genome of Onchocerca volvulus, agent of river blindness
Human onchocerciasis is a serious neglected tropical disease caused by the filarial nematode Onchocerca volvulus that can lead to blindness and chronic disability. Control of the disease relies largely on mass ad...
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Open AccessThe genome of the yellow potato cyst nematode, Globodera rostochiensis, reveals insights into the basis of parasitism and virulence
The yellow potato cyst nematode, Globodera rostochiensis, is a devastating plant pathogen of global economic importance. This biotrophic parasite secretes effectors from pharyngeal glands, some of which were acqu...
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Open AccessThe genomic basis of parasitism in the Strongyloides clade of nematodes
Taisei Kikuchi, Mark Viney, Matthew Berriman and colleagues report the genome sequences of six species of nematodes from the Strongyloides clade of nematodes, including human and animal pathogens, facultative par...
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Open AccessWhole genome resequencing of the human parasite Schistosoma mansoni reveals population history and effects of selection
Schistosoma mansoni is a parasitic fluke that infects millions of people in the develo** world. This study presents the first application of population genomics to S. mansoni based on high-coverage resequencing...
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Giardia duodenalis: New Research Developments in Pathophysiology, Pathogenesis, and Virulence Factors
Giardia duodenalis is a very common, ubiquitous, intestinal protozoan parasite infecting animals and humans. Of the eight distinct genetic assemblages known to date, assemblages A and B a...
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Open AccessWhipworm genome and dual-species transcriptome analyses provide molecular insights into an intimate host-parasite interaction
Matthew Berriman and colleagues report the whole-genome sequences of the human-infective whipworm Trichuris trichiura and the mouse-infective laboratory model Trichuris muris. Their transcriptome analyses and exa...
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Open AccessThe genome and life-stage specific transcriptomes of Globodera pallidaelucidate key aspects of plant parasitism by a cyst nematode
Globodera pallida is a devastating pathogen of potato crops, making it one of the most economically important plant parasitic nematodes. It is also an important model for the biology of cyst nematodes. Cyst nemat...
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Open AccessGenome-wide signatures of convergent evolution in echolocating mammals
By analysing genomic sequences in echolocating mammals it is shown that convergence is not a rare process restricted to a handful of loci but is instead widespread, continuously distributed and commonly driven...
