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Article
Ochratoxin A induces hepatic and renal toxicity in mice through increased oxidative stress, mitochondrial damage, and multiple cell death mechanisms
Ochratoxin A (OTA) is a widespread food toxin produced by Aspergillus ochraceus and other molds. In this study, we developed and established acute OTA toxicity conditions in mice, which received daily oral doses ...
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Article
Intermittent fasting promotes rejuvenation of immunosenescent phenotypes in aged adipose tissue
The aging of white adipose tissue (WAT) involves senescence of adipose stem and progenitor cells (ASPCs) and dysregulation of immune cell populations, serving as a major driver of age-associated adipose dysfun...
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Article
Open AccessMdm1 ablation results in retinal degeneration by specific intraflagellar transport defects of photoreceptor cells
Mouse double minute 1 (Mdm1) might be involved in the function and structure of centrioles and age-related retinal degeneration. However, the mechanism by which Mdm1 deficiency causes retinal degeneration remains...
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Article
Open AccessNintedanib induces senolytic effect via STAT3 inhibition
Selective removal of senescent cells, or senolytic therapy, has been proposed to be a potent strategy for overcoming age-related diseases and even for reversing aging. We found that nintedanib, a tyrosine kina...
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Article
Open AccessInducible Prmt1 ablation in adult vascular smooth muscle leads to contractile dysfunction and aortic dissection
Vascular smooth muscle cells (VSMCs) have remarkable plasticity in response to diverse environmental cues. Although these cells are versatile, chronic stress can trigger VSMC dysfunction, which ultimately lead...
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Article
Open AccessSelenoprotein W ensures physiological bone remodeling by preventing hyperactivity of osteoclasts
Selenoproteins containing selenium in the form of selenocysteine are critical for bone remodeling. However, their underlying mechanism of action is not fully understood. Herein, we report the identification of...
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Article
CD9 induces cellular senescence and aggravates atherosclerotic plaque formation
CD9, a 24 kDa tetraspanin membrane protein, is known to regulate cell adhesion and migration, cancer progression and metastasis, immune and allergic responses, and viral infection. CD9 is upregulated in senesc...
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Article
Open AccessLoss of the dermis zinc transporter ZIP13 promotes the mildness of fibrosarcoma by inhibiting autophagy
Fibrosarcoma is a skin tumor that is frequently observed in humans, dogs, and cats. Despite unsightly appearance, studies on fibrosarcoma have not significantly progressed, due to a relatively mild tumor sever...
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Article
Open AccessThermogenesis-independent metabolic benefits conferred by isocaloric intermittent fasting in ob/ob mice
Intermittent fasting (IF) is an effective dietary intervention to counteract obesity-associated metabolic abnormalities. Previously, we and others have highlighted white adipose tissue (WAT) browning as the ma...
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Article
Open AccessPAR-1 is a novel mechano-sensor transducing laminar flow-mediated endothelial signaling
Recent studies have indicated that protease-activated receptor-1 (PAR-1) is involved in cytoprotective and anti-inflammatory responses in endothelial cells (ECs). However, the role of PAR-1 in laminar flow-med...
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Article
Open AccessIntermittent fasting promotes adipose thermogenesis and metabolic homeostasis via VEGF-mediated alternative activation of macrophage
Intermittent fasting (IF), a periodic energy restriction, has been shown to provide health benefits equivalent to prolonged fasting or caloric restriction. However, our understanding of the underlying mechanis...
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Article
Open AccessProgressive slowdown/prevention of cellular senescence by CD9-targeted delivery of rapamycin using lactose-wrapped calcium carbonate nanoparticles
Cellular senescence, a state of irreversible growth arrest and altered cell function, causes aging-related diseases. Hence, treatment modalities that could target aging cells would provide a robust therapeutic...
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Article
Delayed-onset hearing loss in pediatric candidates for cochlear implantation
The objective of this study was to evaluate the clinical significance of delayed-onset hearing loss in children. Seventy-three children who underwent cochlear implantation (CI) were included. They were divided...
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Article
Inhibitory effects of quercetagetin 3,4′-dimethyl ether purified from Inula japonica on cellular senescence in human umbilical vein endothelial cells
Cellular senescence contributes to tissue and organismal aging, tumor suppression and progress, tissue repair and regeneration, and age-related diseases. Thus, aging intervention might be beneficial for treatm...
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Article
Inhibitory effects of (−)-loliolide on cellular senescence in human dermal fibroblasts
Cellular senescence influences tumor suppression and progress, tissue repair and regeneration, tissue and organismal aging, and age-related diseases. Aging intervention might be an advantageous target for prev...
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Article
RhoGDI2 is associated with HGF-mediated tumor invasion through VEGF in stomach cancer
RhoGDP dissociation inhibitor 2 (RhoGDI2) has been identified as a regulator of tumor metastasis; however, its role in cancer remains controversial. The aims of this study were to analyze RhoGDI2 in gastric ca...
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Article
Quercetin-3-O-β-d-glucuronide isolated from Polygonum aviculare inhibits cellular senescence in human primary cells
Cellular senescence is known to contribute to tissue aging, a variety of age-related diseases, tissue regeneration, and cancer. Therefore, aging intervention might be useful for prevention of aging as well as ...
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Article
Inhibitory effects of juglanin on cellular senescence in human dermal fibroblasts
Cellular senescence contributes to tissue and organismal aging, tumor suppression and progress, tissue repair and regeneration, and age-related diseases. Thus, aging intervention might be a promising target f...
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Article
High-performance liquid chromatographic analysis for quantitation of marker compounds of Artemisia capillaris thunb.
Two stable high-performance liquid chromatography (HPLC) methods were developed that could quantitatively analyze 10 major marker compounds of Artemisia capillaris Thunb and could also distinguish among ‘In**ho’...
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Article
Regulation of HGF-mediated cell proliferation and invasion through NF-κB, JunB, and MMP-9 cascades in stomach cancer cells
Blocking of activator protein-1 activity leads to suppression of growth factor-induced transformation. However, the role of individual components of the Jun family in this process is unclear. Over-expression o...
