4 Result(s)
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Jack Bowden
Statistical Theory and Methods
Statistics for Life Sciences, Medicine, Health Sciences
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Article
Open AccessShould RECOVERY have used response adaptive randomisation? Evidence from a simulation study
The Randomised Evaluation of COVID-19 Therapy (RECOVERY) trial is aimed at addressing the urgent need to find effective treatments for patients hospitalised with suspected or confirmed COVID-19. The trial has ...
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Article
Open AccessThe use of single armed observational data to closing the gap in otherwise disconnected evidence networks: a network meta-analysis in multiple myeloma
Network meta-analysis (NMA) allows for the estimation of comparative effectiveness of treatments that have not been studied in head-to-head trials; however, relative treatment effects for all interventions can...
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Article
Open AccessConfidence intervals for the between-study variance in random-effects meta-analysis using generalised heterogeneity statistics: should we use unequal tails?
Confidence intervals for the between study variance are useful in random-effects meta-analyses because they quantify the uncertainty in the corresponding point estimates. Methods for calculating these confiden...
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Article
Open AccessQuantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Qstatistics
Clinical researchers have often preferred to use a fixed effects model for the primary interpretation of a meta-analysis. Heterogeneity is usually assessed via the well known Q and I 2 statistics, along with the ...
