-
Article
Open AccessDuplicated network meta-analysis in advanced prostate cancer: a case study and recommendations for change
Research overlap and duplication is a recognised problem in the context of both pairwise and network systematic reviews and meta-analyses. As a case study, we carried out a sco** review to identify and exami...
-
Article
Open AccessImplications of analysing time-to-event outcomes as binary in meta-analysis: empirical evidence from the Cochrane Database of Systematic Reviews
Systematic reviews and meta-analysis of time-to-event outcomes are frequently published within the Cochrane Database of Systematic Reviews (CDSR). However, these outcomes are handled differently across meta-an...
-
Article
Meta-analyses based on summary data can provide timely, thorough and reliable evidence: don’t dismiss them yet
-
Article
Open AccessSharing individual participant data: through a systematic reviewer lens
An increasing prevalence of data-sharing models, aimed at making individual participant data (IPD) from clinical trials widely available, should facilitate the conduct of systematic reviews and meta-analyses b...
-
Article
Open AccessIdentifying additional studies for a systematic review of retention strategies in randomised controlled trials: making contact with trials units and trial methodologists
Search strategies for systematic reviews aim to identify all evidence relevant to the research question posed. Reports of methodological research can be difficult to find leading to biased results in systemati...
-
Article
Open AccessThe INVEST project: investigating the use of evidence synthesis in the design and analysis of clinical trials
When designing and analysing clinical trials, using previous relevant information, perhaps in the form of evidence syntheses, can reduce research waste. We conducted the INVEST (INVestigating the use of Eviden...
-
Article
Open AccessThe value of evidence synthesis in randomised controlled trial (RCT) design, conduct and analysis: MRC clinical trials unit (CTU) at UCL experience
-
Article
Open AccessMeasuring the impact of methodological research: a framework and methods to identify evidence of impact
Providing evidence of impact highlights the benefits of medical research to society. Such evidence is increasingly requested by research funders and commonly relies on citation analysis. However, other indicat...
-
Article
Open AccessEvaluation of patient involvement in a systematic review and meta-analysis of individual patient data in cervical cancer treatment
In April 2005, researchers based at the Medical Research Council Clinical Trials Unit, set out to involve women affected by cervical cancer in a systematic review and meta-analysis of individual patient data t...
-
Article
Open AccessQuantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Qstatistics
Clinical researchers have often preferred to use a fixed effects model for the primary interpretation of a meta-analysis. Heterogeneity is usually assessed via the well known Q and I 2 statistics, along with the ...
-
Article
Open AccessPractical methods for incorporating summary time-to-event data into meta-analysis
In systematic reviews and meta-analyses, time-to-event outcomes are most appropriately analysed using hazard ratios (HRs). In the absence of individual patient data (IPD), methods are available to obtain HRs a...
