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Article
Open AccessPrevalence and Correlates of Fearing a Partner During the COVID-19 Pandemic in Britain: Findings from Natsal-COVID
The COVID-19 pandemic and lockdown restrictions introduced personal and relationship stressors that potentially increased the risk of intimate partner violence (IPV) for some. We estimated the population preva...
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Article
Open AccessHuman papillomavirus infection: protocol for a randomised controlled trial of imiquimod cream (5%) versus podophyllotoxin cream (0.15%), in combination with quadrivalent human papillomavirus or control vaccination in the treatment and prevention of recurrence of anogenital warts (HIPvac trial)
Anogenital warts are the second most common sexually transmitted infection diagnosed in sexual health services in England. About 90% of genital warts are caused by human papillomavirus (HPV) types 6 or 11, and...
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Article
Open AccessSuperiority and non-inferiority: two sides of the same coin?
The classification of phase 3 trials as superiority or non-inferiority has become routine, and it is widely accepted that there are important differences between the two types of trial in their design, analysi...
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Article
Open AccessCombined models for pre- and post-treatment longitudinal biomarker data: an application to CD4 counts in HIV-patients
There has been some debate in the literature as to whether baseline values of a measurement of interest at treatment initiation should be treated as an outcome variable as part of a model for longitudinal chan...
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Article
Open AccessFive questions to consider before conducting a stepped wedge trial
Researchers should consider five questions before starting a stepped wedge trial.
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Article
Open AccessDesigning a stepped wedge trial: three main designs, carry-over effects and randomisation approaches
There is limited guidance on the design of stepped wedge cluster randomised trials. Current methodological literature focuses mainly on trials with cross-sectional data collection at discrete times, yet many r...
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Article
Open AccessAnalysis and reporting of stepped wedge randomised controlled trials: synthesis and critical appraisal of published studies, 2010 to 2014
Stepped wedge cluster randomised trials introduce interventions to groups of clusters in a random order and have been used to evaluate interventions for health and wellbeing. Standardised guidance for reportin...
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Article
Open AccessHow important is randomisation in a stepped wedge trial?
In cluster randomised trials, randomisation increases internal study validity. If enough clusters are randomised, an unadjusted analysis should be unbiased. If a smaller number of clusters are included, strati...
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Article
Open AccessExamining the potential public health benefit of offering STI testing to men in amateur football clubs: evidence from cross-sectional surveys
In Britain, young people continue to bear the burden of sexually transmitted infections (STIs) so efforts are required, especially among men, to encourage STI testing. The SPORTSMART study trialled an interven...
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Article
Open AccessQuantifying, displaying and accounting for heterogeneity in the meta-analysis of RCTs using standard and generalised Qstatistics
Clinical researchers have often preferred to use a fixed effects model for the primary interpretation of a meta-analysis. Heterogeneity is usually assessed via the well known Q and I 2 statistics, along with the ...
