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  1. No Access

    Article

    Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence

    Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine dependence, which reduces the likelihood of quitting smoking, is a heritable trait with firmly established associations with se...

    D B Hancock, Y Guo, G W Reginsson, N C Gaddis, S M Lutz, R Sherva… in Molecular Psychiatry (2018)

  2. No Access

    Article

    A genome-wide analysis of the response to inhaled β2-agonists in chronic obstructive pulmonary disease

    Short-acting β2-agonist bronchodilators are the most common medications used in treating chronic obstructive pulmonary disease (COPD). Genetic variants determining bronchodilator responsiveness (BDR) in COPD have...

    M Hardin, M H Cho, M-L McDonald, E Wan, D A Lomas… in The Pharmacogenomics Journal (2016)

  3. Article

    Open Access

    Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence

    We conducted a 1000 Genomes–imputed genome-wide association study (GWAS) meta-analysis for nicotine dependence, defined by the Fagerström Test for Nicotine Dependence in 17 074 ever smokers from five European-...

    D B Hancock, G W Reginsson, N C Gaddis, X Chen, N L Saccone… in Translational Psychiatry (2015)

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