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Article
Genome-wide association study across European and African American ancestries identifies a SNP in DNMT3B contributing to nicotine dependence
Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine dependence, which reduces the likelihood of quitting smoking, is a heritable trait with firmly established associations with se...
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Article
A genome-wide analysis of the response to inhaled β2-agonists in chronic obstructive pulmonary disease
Short-acting β2-agonist bronchodilators are the most common medications used in treating chronic obstructive pulmonary disease (COPD). Genetic variants determining bronchodilator responsiveness (BDR) in COPD have...
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Article
Open AccessGenome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence
We conducted a 1000 Genomes–imputed genome-wide association study (GWAS) meta-analysis for nicotine dependence, defined by the Fagerström Test for Nicotine Dependence in 17 074 ever smokers from five European-...
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Article
Diagnostic capabilities of fractal dimension and mandibular cortical width to identify men and women with decreased bone mineral density
Dental panoramic radiographs could be used to screen for osteopenia. We found the fractal dimension to be a good discriminator of osteopenia in both men and women but that the mandibular cortical width (MCW) d...
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Article
Omega-3 fatty acids and lipoprotein associated phospholipase A2 in healthy older adult males and females
Lipoprotein associated phospholipase A2 (Lp-PLA2) is a novel inflammatory factor that has been independently associated with stroke and cardiovascular disease (CVD). Omega-3 fats have been implicated in reducing ...
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Article
Adults with type 1 diabetes eat a high-fat atherogenic diet that is associated with coronary artery calcium
Coronary heart disease is the leading cause of mortality among people with type 1 diabetes. Diet is an important lifestyle factor that relates to risk of CHD. The aim of this study was to examine how diet and ...
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Article
The apolipoprotein A-IV Gln360His polymorphism predicts progression of coronary artery calcification in patients with type 1 diabetes
Individuals with type 1 diabetes have an increased incidence of coronary artery disease (CAD) and a higher risk of cardiovascular death compared with individuals of the same age in the general population. Whil...
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Article
Measurement of abdominal fat by CT compared to waist circumference and BMI in explaining the presence of coronary calcium
OBJECTIVE: To evaluate the association between standard and computed tomography (CT)-based measures of obesity and subclinical atherosclerosis, defined as coronary artery calcium (CAC) by Electron Beam Computed T...
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Article
Lipoprotein lipase gene variants and risk of coronary disease: a quantitative analysis of population-based studies
The purpose of this study is to quantify the magnitude of the association between common variants in the lipoprotein lipase gene and coronary disease, based on published population-based studies. Fourteen stud...
