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  1. No Access

    Article

    Platelet-tissue interaction: Role of platelet-activating factor (PAF-acether)

    The platelet-activating factor, of PAF-acether, is a phospholipid derivative that is a potent aggregating agent. It is formed by platelets themselves and also by basophils, neutrophils, monocytes and macrophag...

    B. B. Vargaftig, M. Chignard, J. Lefort, J. Benveniste in Agents and Actions (1980)

  2. No Access

    Article

    Bronchoconstriction induced by intratracheal administration of platelet-activating factor (PAF-acether) in baboons

    Intratracheal administration of PAF-acether (60 μg.kg−1) was performed in six premedicated, curarized and mechanically ventilated baboons. Whereas intratracheal administration of an equal amount of solvent (200μl...

    A. Denjean, B. Arnoux, J. Benveniste, A. Lockhart, R. Masse in Agents and Actions (1981)

  3. No Access

    Article

    Release of PAF-acether from human blood monocytes

    Stimulation of human blood monocytes with ionophore A 23187 induced the release of platelet-activating factor (PAF-acether). Phagocytosis of zymosan, coated or not with complement, bacteria or immune complexes...

    B. Arnoux, E. Jouvin-Marche, A. Arnoux, J. Benveniste in Agents and Actions (1982)

  4. No Access

    Article

    Platelet-activating factor (PAF-acether): Historical background and definition

    The platelet-activating factor (PAF-acether) was first described as released from sensitized basophils. It is now recognized as a mediator of inflammation, since it is released from most stimulated pro-inflamm...

    J. Benveniste in Agents and Actions (1982)

  5. No Access

    Article

    Inhibition of rat mast cell degranulation by verapamil

    Calcium antagonists, e.g. verapamil, prevent exercise-induced asthma. This protective effect may proceed from inhibition of contraction of bronchial smooth muscle, release of mediators by primary effector cell...

    A. Legrand, J. Cerrina, C. Bonne, A. Lockhart, J. Benveniste in Agents and Actions (1984)

  6. No Access

    Chapter and Conference Paper

    Paf-acether (Platelet-activating Factor)

    Platelet-activating factor was first described as originating from IgE-sensitized rabbit basophils challenged with the specific allergen. When its structure, 1-O- alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine wa...

    J. Benveniste in New Trends in Allergy II (1986)

  7. No Access

    Chapter

    PAF-acether (Platelet Activating Factor)

    When basophils, which were derived from sensitized rabbits, were challenged with a specific allergen a substance was extracted which was capable of aggregating rabbit platelets [3]. Since its initial detection...

    B. Arnoux, C. Brink, J. Benveniste in Highlights in Asthmology (1987)

  8. No Access

    Article

    Renal effects of platelet-activating factor in the rat

    The renal glomerular and tubular effects of the platelet-activating factor (Paf-acether) were studied, by clearance techniques, in acutely thyroparathyroidectomized Brattleboro rats infused with Paf-acether at...

    G. Friedlander M.D., E. Pirotzky, C. Amiel, J. Benveniste in Agents and Actions (1987)

  9. No Access

    Article

    Monoclonal IgE-mediated cardiac hypersensitivity reactions in the guinea-pig

    Isolated heart preparations were prepared from guinea-pigs passively sensitized with mouse anti-DNP monoclonal IgE to study hemodynamic parameters and histamine release upon antigen challenge (DNP-BSA). In the...

    Y. Denizot, J. Boudet, C. Burtin, I. Marro, J. Benveniste in Agents and Actions (1990)

  10. No Access

    Article

    Decrease of ciliary beat frequency by platelet activating factor: Protective effect of ketotifen

    The ciliary beat frequency (CBF) of the tracheal epithelial cells controls in part the respiratory tract mucociliary transport efficiency. We investigated the effects on CBF of PAF-acether (PAF) and its metabo...

    L. Kahhak, A. Roche, C. Dubray, C. Arnoux, J. Benveniste in Inflammation Research (1996)