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Article
The pharmacology of slow reacting substance C and of arachidonic acid
Administration of nonsteroid anti-inflammatory drugs (AID) inhibits hypotension and bronchoconstriction induced by the polyunsaturated prostaglandin (PG) precursor arachidonic acid (AA) and by slow reacting su...
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Article
Selective synthesis of a secretory phospholipase A2 during adherence of guinea-pig alveolar macrophages
We have previously shown that freshly collected guinea-pig alveolar macrophages (AM) showed low levels of sPLA2 activity. This activity increased progressively in cultured AM, to reach levels 40–50-fold above bas...
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Article
Lung responsiveness to antigen in sensitised mice of different strains
A new model of the isolated perfused lung from different strains of mice was developed. Lungs from Swiss, Balb/C and CBA mice actively sensitised to ovalbumin were challenged intratracheally (i.t.) by antigen ...
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Article
Dissociation between LPS-induced bronchial hyperreactivity and airway edema in the guinea-pig
The interactions between LPS-induced bronchial hyper-reactivity (BHR) and lung inflammation (LI) were investigated. LPS-induced LI was assessed with the augmented alveolo-capillary permeability (ACP) and with ...
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Article
Interactions between cyclic AMP stimulating drugs and PAF-acether in guinea-pig alveolar macrophages
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Article
Enhancement of the phospholipase A2 activity in fMLP-treated guinea-pig alveolar macrophages
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Article
Prostaglandin E2 and salbutamol are less effective in raising cAMP levels of alveolar macrophages from ovalbumin-sensitized guinea-pigs as compared to controls
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Article
Antagonists of PAF-acether do not suppress thrombin-induced aggregation of ADP-deprived and aspirin-treated human platelets
Four chemically distinct PAF-acether antagonists were used to test the hypothesis that the cyclooxygenase and ADP-independent thrombin-induced aggregation of human platelets is due to PAF-acether. The compouds...
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Chapter and Conference Paper
Morphological and Pharmacological Evidences for the Participation of PAF-Acether in Anaphylactic Shock in the Guinea-Pig
Anaphylaxis in the guinea-pig is widely used as a model for human asthma. Nevertheless, no ultrastructural morphological studies of the anaphylactic shock in this animal were reported until now. Beside histami...
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Article
Platelet involvement in rat paw edema induced by 2-methoxy-PAF
PAF-acether (PAF) or 2-methoxy-PAF (2-MX) caused a dose-dependent paw edema showing a 1: 25 ratio between their inflammatory activities. 2-MX caused a thrombocytopenia, whereas PAF did not alter the number of ...
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Article
Involvement of leukotrienes and PAF-acether in the increased microvascular permeability of the rabbit retina
The effects of intravenous injection of PAF-acether and of leukotrienes LTB4 and LTD4 on rabbit retina were determinedin vivo in the unanaesthetized animal. PAF-acether induced an intense ischemia accompanied by ...
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Article
Dissociation between inhibition of phospholipid methylation and production of PAF-acether by rabbit platelets
Platelet-activating-factor (PAF-acether, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is formed by and released from rabbit platelets stimulated with thrombin, with the ionophore A23187, with collagen an...
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Article
Pharmacological properties of PAF-acether in the guinea-pig: Platelet-dependent and independent reactions
Thein vivo effects of PAF-acether in the guinea-pig are reviewed, particularly with respect to bronchoconstriction and to platelets, the former being suppressed when the latter are depleted. Bronchoconstriction b...
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Article
Editorial
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Article
Platelet-activating factor (PAF-acether): Thromboxane-independent synergism with adrenaline on human platelets and recent insights into its mode of action
The mode of action of PAF-acether on human and rabbit plasma-free platelets is reviewed. PAF-acether and adrenaline synergize to trigger aggregation of human platelets, and this synergism is refractory to aspi...
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Article
Dissociation of platelet activation from transmethylation of their membrane phospholipids
In cell membranes, two different methyltransferases catalyse the conversion of phosphatidylethanolamine (PE) into phosphatidylcholine (PC) using S-adenosylmethionine as methyl donor. This methylating process may ...
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Article
Editorial
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Article
Platelet-tissue interaction: Role of platelet-activating factor (PAF-acether)
The platelet-activating factor, of PAF-acether, is a phospholipid derivative that is a potent aggregating agent. It is formed by platelets themselves and also by basophils, neutrophils, monocytes and macrophag...
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Article
The role of platelet-activating factor in platelet aggregation
PLATELET aggregation is mediated by at least three distinct mechanisms1,2. The first involves the release of ADP and is inhibited by its conversion to ATP by the combination of creatine phosphate and creatine pho...
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Chapter
Snake Venoms as an Experimental Tool to Induce and Study Models of Microvessel Damage
The catchwords of this chapter came from a scientist whose significant work covers two fields: pharmacology and experimental pathology. The above motto (Selye, 1964) is thus a true reflection of his doublefold pr...
