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Article
Open AccessEμ and 3′RR IgH enhancers show hierarchic unilateral dependence in mature B-cells
Enhancer and super-enhancers are master regulators of cell fate. While they act at long-distances on adjacent genes, it is unclear whether they also act on one another. The immunoglobulin heavy chain (IgH) loc...
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Article
Genes encoding multiple forms of phospholipase A2 are expressed in immature forms of human leukemic blasts
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Article
Concentrations of serum leukemia inhibitory factor (LIF) in patients with hematologic malignances
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Platelet-Activating Factor: Biosynthesis, Biodegradation, Actions
Some of the most potent inflammatory mediators share a lipidic origin. Upon cell activation, the action of lipases on membrane phospholipids produces free fatty acids and the phospholipid backbone. Among the f...
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Article
Human bone marrow fibroblasts - an overview of their characterization, proliferation and inflammatory mediator production
Bone marrow fibroblasts regulate hematopoiesis by interacting directly (cell-to-cell contact) with hematopoietic cells and by secreting regulatory molecules (such as GM-CSF, M-CSF, IL6 and LIF) that modulate h...
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Article
Significance and regulation of gastric secretion of platelet-activating factor (PAF-Acether) in man
Platelet-activating factor (PAF) has been implicated in the pathogenesis of acute inflammatory and ulcerative diseases of the upper gastrointestinal tract. In the present study, we compared the gastric output ...
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Article
Monoclonal IgE-mediated cardiac hypersensitivity reactions in the guinea-pig
Isolated heart preparations were prepared from guinea-pigs passively sensitized with mouse anti-DNP monoclonal IgE to study hemodynamic parameters and histamine release upon antigen challenge (DNP-BSA). In the...