Abstract
The platelet-activating factor (PAF-acether) was first described as released from sensitized basophils. It is now recognized as a mediator of inflammation, since it is released from most stimulated pro-inflammatory cells. It has a unique phospholipid structure and, as yet, is the most potent platelet-activating agent acting at the 1×10−12 to 1×10−10 M level. It also degranulates and attracts neutrophils. Its release from alveolar macrophages might play a role in the onset of bronchoconstriction in experimental animals and in man. Thus, PAF-acether is gaining increasing importance as a major intermediate of inflammatory reactions.
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Benveniste, J. Platelet-activating factor (PAF-acether): Historical background and definition. Agents and Actions 12, 700–701 (1982). https://doi.org/10.1007/BF01965082
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DOI: https://doi.org/10.1007/BF01965082