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Chapter
Auswirkungen von Lupus auf die Durchblutung
Ziele des Kapitels sind: 1. Der Leser soll durch den Lupus verursachte oder davon unabhängige, entzündliche und nichtentzündliche Ursachen für kalte/verfärbte Extremitäten unterscheiden und gefährliche Verläuf...
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Article
Safety and efficacy of the combination of pegylated interferon-α2b and dasatinib in newly diagnosed chronic-phase chronic myeloid leukemia patients
Dasatinib (DAS) and interferon-α have antileukemic and immunostimulatory effects and induce deep responses in chronic myeloid leukemia (CML). We assigned 40 newly diagnosed chronic-phase CML patients to receiv...
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Article
Open AccessThe concept of treatment-free remission in chronic myeloid leukemia
The advent of tyrosine kinase inhibitors (TKI) into the management of patients with chronic myeloid leukemia (CML) has profoundly improved prognosis. Survival of responders is approaching that of the general p...
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Article
Increased prevalence of prior malignancies and autoimmune diseases in patients diagnosed with chronic myeloid leukemia
We recently reported an increased incidence of second malignancies in chronic myeloid leukemia (CML) patients treated with tyrosine kinase inhibitors (TKI). To elucidate whether this increase may be linked, no...
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Article
Allelic variation in CRHR1 predisposes to panic disorder: evidence for biased fear processing
Corticotropin-releasing hormone (CRH) is a major regulator of the hypothalamic–pituitary–adrenal axis. Binding to its receptor CRHR1 triggers the downstream release of the stress response-regulating hormone co...
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Article
Open AccessMAOA gene hypomethylation in panic disorder—reversibility of an epigenetic risk pattern by psychotherapy
Epigenetic signatures such as methylation of the monoamine oxidase A (MAOA) gene have been found to be altered in panic disorder (PD). Hypothesizing temporal plasticity of epigenetic processes as a mechanism of s...
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Article
IL1RAP expression as a measure of leukemic stem cell burden at diagnosis of chronic myeloid leukemia predicts therapy outcome
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Article
Open AccessInhibition of Notch1 signaling overcomes resistance to the death ligand Trail by specificity protein 1-dependent upregulation of death receptor 5
The Notch1 signaling pathway contributes to tumorigenesis by influencing differentiation, proliferation and apoptosis. Here, we demonstrate that inhibition of the Notch1 signaling pathway sensitizes glioblasto...
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Article
Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma
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Article
The mutational pattern of primary lymphoma of the central nervous system determined by whole-exome sequencing
To decipher the mutational pattern of primary CNS lymphoma (PCNSL), we performed whole-exome sequencing to a median coverage of 103 × followed by mutation verification in 9 PCNSL and validation using Sanger se...
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Article
A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact
Prospective identification of patients with chronic lymphocytic leukemia (CLL) destined to progress would greatly facilitate their clinical management. Recently, whole-genome DNA methylation analyses identifie...
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Article
Placental Schistosoma haematobium infection in a German returnee from Malawi
Schistosomiasis is a widespread helminthic infection which sometimes may affect travelers to endemic areas. We report on a case of urogenital and placental schistosomiasis in a 28-year-old German woman who had...
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Article
Open AccessModeling chronic myeloid leukemia in immunodeficient mice reveals expansion of aberrant mast cells and accumulation of pre-B cells
Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm that, if not treated, will progress into blast crisis (BC) of either myeloid or B lymphoid phenotype. The BCR-ABL1 fusion gene, encoding a constitut...
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Article
Open AccessThe functional −1019C/G HTR1A polymorphism and mechanisms of fear
Serotonin receptor 1A gene (HTR1A) knockout mice show pronounced defensive behaviour and increased fear conditioning to ambiguous conditioned stimuli. Such behaviour is a hallmark of pathological human anxiety, a...
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Article
Einfluss der CMD auf die mechanische Schmerzschwelle außerhalb der Kopf-Gesichts-Region
Bis dato konnte keine Studie eine Veränderung der Druckempfindlichkeit der myofaszialen Tender- oder Triggerpunkte (MTrP) bei Patienten mit kraniomandibulärer Dysfunktion (CMD) im extratrigeminalen Versorgungs...
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Article
Möglichkeiten und Grenzen patientenberichteter Endpunkte am Beispiel des systemischen Lupus erythematodes und der LuLa-Studie
Patientenberichtete Endpunkte bzw. „patient-reported outcomes“ (PRO) haben in den letzten drei Jahrzehnten eine zunehmende Bedeutung in der Beurteilung von Krankheitsverläufen und Therapieansprechen erfahren. ...
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Article
55-jährige Patientin mit Husten, Fieber, Gelenkschwellungen und Exanthem nach einem Urlaub in Ecuador
Eine 55-jährige Patientin stellte sich 16 Monate nach Aufenthalt in Ecuador mit einem unklaren Lungenbefund vor. Es bestanden Nachtschweiß und allgemeine Schwäche. In der Computertomographie zeigte sich ein 14...
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Article
Operationstechnik posterolaterale Stabilisierung
Die posterolateralen Strukturen (PLS) stellen den Hauptstabilisator für die tibiale Außenrotation in geringeren Flexionsgraden dar. Verletzungen der posterolateralen Gelenkecke treten dabei häufig in Kombinati...
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Article
RNA-seq identifies clinically relevant fusion genes in leukemia including a novel MEF2D/CSF1R fusion responsive to imatinib
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Article
MAOA and mechanisms of panic disorder revisited: from bench to molecular psychotherapy
Panic disorder with agoraphobia (PD/AG) is a prevalent mental disorder featuring a substantial complex genetic component. At present, only a few established risk genes exist. Among these, the gene encoding monoam...
