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Article
Open AccessDistinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging
People living with HIV (PLWH), even when viral replication is controlled through antiretroviral therapy (ART), experience persistent inflammation. This inflammation is partly attributed to intestinal microbial...
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Article
Open AccessCD8+ T cells control SIV infection using both cytolytic effects and non-cytolytic suppression of virus production
Whether CD8+ T lymphocytes control human immunodeficiency virus infection by cytopathic or non-cytopathic mechanisms is not fully understood. Multiple studies highlighted non-cytopathic effects, but one hypothesi...
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Article
Open AccessProlonged experimental CD4+ T-cell depletion does not cause disease progression in SIV-infected African green monkeys
CD4+ T-cell depletion is a hallmark of HIV infection, leading to impairment of cellular immunity and opportunistic infections, but its contribution to SIV/HIV-associated gut dysfunction is unknown. Chronically SI...
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Open AccessShifts in microbial diversity, composition, and functionality in the gut and genital microbiome during a natural SIV infection in vervet monkeys
The microbiota plays an important role in HIV pathogenesis in humans. Microbiota can impact health through several pathways such as increasing inflammation in the gut, metabolites of bacterial origin, and micr...
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Article
Open AccessImmunosuppressive effect and global dysregulation of blood transcriptome in response to psychosocial stress in vervet monkeys (Chlorocebus sabaeus)
Psychosocial stressors - life events that challenge social support and relationships - represent powerful risk factors for human disease; included amongst these events are relocation, isolation and displacemen...
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Open AccessAuthor Correction: Macrophage-associated wound healing contributes to African green monkey SIV pathogenesis control
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Open AccessMacrophage-associated wound healing contributes to African green monkey SIV pathogenesis control
Natural hosts of simian immunodeficiency virus (SIV) avoid AIDS despite lifelong infection. Here, we examined how this outcome is achieved by comparing a natural SIV host, African green monkey (AGM) to an AIDS...
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Article
Open AccessExperimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection
Mucosal damage to the gastrointestinal (GI) tract with resulting microbial translocation is hypothesized to significantly contribute to the heightened and persistent chronic inflammation and immune activation ...
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Article
Open AccessUsing the Pathogenic and Nonpathogenic Nonhuman Primate Model for Studying Non-AIDS Comorbidities
With the advent of antiretroviral therapy that can control virus replication below the detection levels of conventional assays, a new clinical landscape of AIDS emerged, in which non-AIDS complications prevail...
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Open AccessExperimental depletion of CD8+ cells in acutely SIVagm-Infected African Green Monkeys results in increased viral replication
In vivo CD8+ cell depletions in pathogenic SIV infections identified a key role for cellular immunity in controlling viral load (VL) and disease progression. However, similar studies gave discordant results in ch...
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Article
Open AccessWhere the Wild Things Are: Pathogenesis of SIV Infection in African Nonhuman Primate Hosts
African nonhuman primates that are natural hosts of simian immunodeficiency virus (SIV) are generally spared from disease progression. Pathogenic and nonpathogenic SIV infections share some major features: hig...
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Article
Toward an AIDS vaccine: lessons from natural simian immunodeficiency virus infections of African nonhuman primate hosts
The design of an effective AIDS vaccine has eluded the efforts of the scientific community to the point that alternative approaches to classic vaccine formulations have to be considered. We propose here that H...
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Open AccessDistinct expression profiles of TGF-β1 signaling mediators in pathogenic SIVmac and non-pathogenic SIVagm infections
The generalized T-cell activation characterizing HIV-1 and SIVmac infections in humans and macaques (MACs) is not found in the non-pathogenic SIVagm infection in African green monkeys (AGMs). We have previousl...
