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Article
Distinct SIV-specific CD8+ T cells in the lymph node exhibit simultaneous effector and stem-like profiles and are associated with limited SIV persistence
Human immunodeficiency virus (HIV) cure efforts are increasingly focused on harnessing CD8+ T cell functions, which requires a deeper understanding of CD8+ T cells promoting HIV control. Here we identifiy an anti...
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Article
Open AccessDistinct transcriptomic and epigenomic modalities underpin human memory T cell subsets and their activation potential
Human memory T cells (MTC) are poised to rapidly respond to antigen re-exposure. Here, we derived the transcriptional and epigenetic programs of resting and ex vivo activated, circulating CD4+ and CD8+ MTC subset...
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Article
Open AccessProlonged experimental CD4+ T-cell depletion does not cause disease progression in SIV-infected African green monkeys
CD4+ T-cell depletion is a hallmark of HIV infection, leading to impairment of cellular immunity and opportunistic infections, but its contribution to SIV/HIV-associated gut dysfunction is unknown. Chronically SI...
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Article
Open AccessButyrate administration is not sufficient to improve immune reconstitution in antiretroviral-treated SIV-infected macaques
Defective gastrointestinal barrier function and, in turn, microbial translocation have been identified as significant contributors to persistent inflammation in antiretroviral (ARV)-treated people living with ...
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Article
Open AccessLatent Membrane Protein 1 as a molecular adjuvant for single-cycle lentiviral vaccines
Molecular adjuvants are a promising method to enhance virus-specific immune responses and protect against HIV-1 infection. Immune activation by ligands for receptors such as CD40 can induce dendritic cell acti...
