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  1. No Access

    Article

    β-catenin confers resistance to PI3K and AKT inhibitors and subverts FOXO3a to promote metastasis in colon cancer

    The crosstalk between the transcriptional activity of β-catenin and FOXO3a reveals unexpected pro-metastatic cooperative effects of these pathways through concurrent modulation of cell adhesion and motility pr...

    Stephan P Tenbaum, Paloma Ordóñez-Morán, Isabel Puig, Irene Chicote… in Nature Medicine (2012)

  2. No Access

    Article

    The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer

    Several non-hypercalcemic analogs of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) show antitumor activity in a subset of cancer patients. High vitamin D receptor (VDR) expression, which is associated with good prognos...

    Héctor G Pálmer, María Jesús Larriba, José Miguel García… in Nature Medicine (2004)