6 Result(s)
within
Igor Theurl
Molecular Medicine
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Article
Open Access“Pum** iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels
Macrophages reside in virtually every organ. First arising during embryogenesis, macrophages replenish themselves in the adult through a combination of self-renewal and influx of bone marrow-derived monocytes....
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Article
On-demand erythrocyte disposal and iron recycling requires transient macrophages in the liver
Damaged erythrocytes accumulate in various pathological conditions, such as hemolytic anemia, anemia of inflammation, and sickle cell disease. In mice challenged with damaged erythorcytes, a monocyte subset mi...
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Article
Local proliferation dominates lesional macrophage accumulation in atherosclerosis
Macrophages are abundant in atherosclerotic plaques and are a pivotal cell type in plaque formation and progression. But how do they get there? Filip Swirski and his colleagues show that, contrary to most prev...
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Article
Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression
Hepcidin, a small cationic liver derived peptide, is a master regulator of body iron homeostasis. Cytokines and iron availability have so far been identified as regulators of hepcidin expression. Herein, we in...
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Article
Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1
Hereditary hemochromatosis and transfusional iron overload are frequent clinical conditions associated with progressive iron accumulation in parenchymal tissues, leading to eventual organ failure. We have disc...
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Article
Duodenal HFE expression and hepcidin levels determine body iron homeostasis: modulation by genetic diversity and dietary iron availability
HFE affects the interaction of transferrin bound iron with transferrin receptors (TfR) thereby modulating iron uptake. To study genetically determined differences in HFE expression we examined individual HFE l...
