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Article
Open AccessThe combination of supervised and unsupervised learning based risk stratification and phenoty** in pulmonary arterial hypertension—a long-term retrospective multicenter trial
Accurate risk stratification in pulmonary arterial hypertension (PAH), a devastating cardiopulmonary disease, is essential to guide successful therapy. Machine learning may improve risk management and harness ...
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Article
Evaluating the clinical utility and sensitivity of SARS-CoV-2 antigen testing in relation to RT-PCR Ct values
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Article
Open AccessIron deficiency or anemia of inflammation?
Iron deficiency and immune activation are the two most frequent causes of anemia, both of which are based on disturbances of iron homeostasis. Iron deficiency anemia results from a reduction of the body’s iron...
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Article
Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression
Hepcidin, a small cationic liver derived peptide, is a master regulator of body iron homeostasis. Cytokines and iron availability have so far been identified as regulators of hepcidin expression. Herein, we in...
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Article
Pyopneumothorax due to Streptococcus milleri
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Duodenal HFE expression and hepcidin levels determine body iron homeostasis: modulation by genetic diversity and dietary iron availability
HFE affects the interaction of transferrin bound iron with transferrin receptors (TfR) thereby modulating iron uptake. To study genetically determined differences in HFE expression we examined individual HFE l...