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Article
Nimotuzumab and radiotherapy for treatment of newly diagnosed diffuse intrinsic pontine glioma (DIPG): a phase III clinical study
Diffuse intrinsic pontine glioma (DIPG) is a devastating cancer of childhood and adolescence.
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Article
MRD response in a refractory paediatric T-ALL patient through anti-programmed cell death 1 (PD-1) Ab treatment associated with induction of fatal GvHD
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Article
Open AccessA human immunodeficiency syndrome caused by mutations in CARMIL2
Human T-cell function is dependent on T-cell antigen receptor (TCR) and co-signalling as evidenced by immunodeficiencies affecting TCR-dependent signalling pathways. Here, we show four human patients with EBV+ di...
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Article
Open AccessATG5 can regulate p53 expression and activation
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Article
MiRNome and transcriptome aided pathway analysis in human regulatory T cells
Owing to their manifold immune regulatory functions, regulatory T cells (Treg) have received tremendous interest as targets for therapeutic intervention of diverse immunological pathologies or cancer. Directed...
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Article
Instantaneous and potential radiation effect on underplanted European beech below Norway spruce canopy
In even-aged, 120-year-old Norway spruce stands with underplanted beech (in 1995) four permanent research plots were established, each 100 × 100 m in size. Twelve subplots were selected on each plot along a li...
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Article
Free asymmetric dimethylarginine (ADMA) is low in children and adolescents with classical phenylketonuria (PKU)
Free asymmetric dimethylarginine (ADMA) is a competitive inhibitor of the nitric oxide synthases (NOS). Suppression of nitric oxide (NO) synthesis increases the risk of atherosclerosis. Nevertheless, in the co...
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Article
Favorable outcome in infants with AML after intensive first- and second-line treatment: an AML-BFM study group report
Infants <1 year of age have a high prevalence of prognostically unfavorable leukemias and a presumed susceptibility to treatment-related toxicities. A total of 125 infants with acute myeloid leukemia (AML) wer...
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Article
Knochenschmerzen im Kindes- und Jugendalter
Schmerzen des Bewegungsapparats sind ein relativ häufiger Vorstellungsgrund in der Pädiatrie. Dem Knochenschmerz können einerseits maligne Erkrankungen, wie primäre Knochentumoren, Knochenmetastasen und Knoche...
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Article
Successful SCT for Nijmegen breakage syndrome
Nijmegen breakage syndrome (NBS) is characterized by chromosomal instability, radiation hypersensitivity, characteristic facial appearance, immunodeficiency and strong predisposition to lymphoid malignancy. Tr...
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Article
Viable neutrophils release mitochondrial DNA to form neutrophil extracellular traps
Neutrophil extracellular traps (NETs) represent extracellular structures able to bind and kill microorganisms. It is believed that they are generated by neutrophils undergoing cell death, allowing these dying ...
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Chapter
Clustered Distribution of Tree Roots and Soil Water Exploitation
A substantial number of experiments have shown root proliferation and concentration in nutrient-rich patches. This article focuses on root clustering observed on tree roots in forest stands and water uptake wi...
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Article
Digitale Ischämien bei einer Patientin mit großzelligem Lungenkarzinom
Eine seltene Form einer Paraneoplasie kann ein Raynaud-Phänomen mit akraler Ischämie bis hin zur Nekrose sein. Wir berichten über eine Patientin mit einem onkologisch austherapierten metastasierenden Bronchial...
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Chapter and Conference Paper
Map** uncompensated spins in exchange-biased systems by high resolution and quantitative magnetic force microscopy
Magnetic Force Microscopy is an ideal tool to image magnetic stray fields emanating from surfaces but also from hidden interfaces of magnetic samples. A lateral resolution of 10nm is routinely obtained on flat...
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Chapter
Pediatrie PET: Indications and Value of Multimodal Imaging
Magnetic resonance imaging (MRI) and positron emission tomography (PET) are diagnostic imaging modalities that allow visualization of morphological as well as functional features of different diseases in child...
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Article
Neue Therapieansätze in der pädiatrischen Onkologie
Das etablierte Therapiekonzept in der pädiatrischen Onkologie beruht neben Operation und Bestrahlung auf zytostatischer Chemotherapie. Durch die Kombination dieser 3 Modalitäten im Rahmen von kontrollierten, m...
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Article
Ernährungsstatus krebskranker Kinder während Chemotherapie
Bei Eltern und Ärzten besteht häufig die Befürchtung, dass krebskranke Kinder im Lauf der Chemotherapie Zeichen einer Mangelernährung entwickeln. Wir bestimmten deshalb bei 18 Kindern mit akuten Leukämien und...
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Article
Intraabdominelle Raumforderung bei einem Neugeborenen
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Article
Bildgebende Diagnostik des kindlichen Neuroblastoms
123I-Metaiodobenzylguanidin(MIBG)-Szintigraphie und Magnetresonanztomographie (MRT) wurden hinsichtlich der Erfassung einzelner Neuroblastomläsionen sowie der Bewertung des Informationsgewinns bei kombinierter B...
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Article
Importance of mineral nutrition for photosynthesis and growth of Quercus petraea, Fagus sylvatica and Acer pseudoplatanus planted under Norway spruce canopy
The aim of this study was to combine data on photosynthetic performance, growth and mineral nutrition of Quercus petraea, Fagus sylvatica and Acer pseudoplatanus growing six years under a Norway spruce canopy. Th...
