11 Result(s)

Article

Two-by-two factorial randomised study within a trial (SWAT) to evaluate strategies for follow-up in a randomised prevention trial

Failure to collect outcome data in randomised trials can result in bias and loss of statistical power. Further evaluations of strategies to increase retention are required. We assessed the effectiveness of two...

Lucy E. Bradshaw, Alan A. Montgomery, Hywel C. Williams, Joanne R. Chalmers… in Trials (2020)

Article

Feasibility of weekly participant-reported data collection in a pragmatic randomised controlled trial in primary care: experiences from the BATHE trial (Bath Additives for the Treatment of cHildhood Eczema)

Patient-reported outcomes measures in clinical trials ensure that evaluations of effectiveness focus on outcomes that are important to patients. In relapsing-remitting conditions, such as eczema, repeated meas...

Beth Stuart, Kate Rumsby, Miriam Santer, Matthew J. Ridd, Nick A. Francis… in Trials (2018)

Article

Effectiveness and cost-effectiveness of daily all-over-body application of emollient during the first year of life for preventing atopic eczema in high-risk children (The BEEP trial): protocol for a randomised controlled trial

Atopic eczema (AE) is a common skin problem that impairs quality of life and is associated with the development of other atopic diseases including asthma, food allergy and allergic rhinitis. AE treatment is a ...

Joanne R. Chalmers, Rachel H. Haines, Eleanor J. Mitchell, Kim S. Thomas… in Trials (2017)

Article

A multi-centre, parallel group superiority trial of silk therapeutic clothing compared to standard care for the management of eczema in children (CLOTHES Trial): study protocol for a randomised controlled trial

Eczema is a chronic, itchy skin condition that can have a large impact on the quality of life of patients and their families. People with eczema are often keen to try out non-pharmacological therapies like sil...

Eleanor F. Harrison, Rachel H. Haines, Fiona Cowdell, Tracey H. Sach… in Trials (2015)

Article

Achieving consensus over the assessment of clinical signs in eczema trials

Kim S Thomas, Jochen Schmitt, Phyllis I Spuls, Eric Simpson, Masutaka Furue… in Trials (2015)

Article

UK Dermatology Clinical Trials Network’s STOP GAP trial (a multicentre trial of prednisolone versus ciclosporin for pyoderma gangrenosum): protocol for a randomised controlled trial

Pyoderma gangrenosum (PG) is a rare inflammatory skin disorder characterised by painful and rapidly progressing skin ulceration. PG can be extremely difficult to treat and patients often require systemic immun...

Fiona F Craig, Kim S Thomas, Eleanor J Mitchell, Hywel C Williams, John Norrie… in Trials (2012)

Article

The value of the pragmatic-explanatory continuum indicator summary wheel in an ongoing study: the bullous pemphigoid steroids and tetracyclines study

The Pragmatic-Explanatory Continuum Indicator Summary (PRECIS) tool is intended to be used in the design phase of trials to help investigative teams design trials in-line with their purpose. Our team applied t...

Daniel J Bratton, Andrew J Nunn, Fenella Wojnarowska, Gudula Kirtschig… in Trials (2012)

Article

Problems in the reporting of acne clinical trials: a spot check from the 2009 Annual Evidence Update on Acne Vulgaris

In the course of producing the 2009 NHS Evidence - skin disorders Annual Evidence Update on Acne Vulgaris, 25 randomised controlled trials were examined. From these, at least 12 potentially serious problems of...

John R Ingram, Douglas JC Grindlay, Hywel C Williams in Trials (2010)

Article

The SINS trial: A randomised controlled trial of excisional surgery versus imiquimod 5% cream for nodular and superficial basal cell carcinoma

Basal cell carcinoma is the commonest human cancer. Despite increasing incidence it remains poorly researched. While not life threatening it can cause significant cosmetic disfigurement. Imiquimod, a cream whi...

Mara Ozolins, Hywel C Williams, Sarah J Armstrong, Fiona J Bath-Hextall in Trials (2010)

Article

Cars, CONSORT 2010, and Clinical Practice

Just like you would not buy a car without key information such as service history, you would not "buy" a clinical trial report without key information such as concealment of allocation. Implementation of the u...

Hywel C Williams in Trials (2010)

Article

Feasibility study to inform the design of a UK multi-centre randomised controlled trial of prophylactic antibiotics for the prevention of recurrent cellulitis of the leg

This paper describes the results of a feasibility study for a randomised controlled trial (RCT).

Kim S Thomas, Neil H Cox, Boki SP Savelyich, Debbie Shipley, Sarah Meredith… in Trials (2007)